Research

Publications, projects, and academic contributions

402 total publications spanning 328 peer-reviewed papers and book chapters, 69 conference abstracts, and 5 theses and technical reports.

Peer-Reviewed Articles & Book Chapters

2025

Effects of exercise on cognition and Alzheimer’s biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study

Baker, Laura D, Pa, Judy A, Katula, Jeffrey A, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 21(4) | 2025 | Article

Topics: Alzheimer’s disease Mild cognitive impairment Exercise intervention EXERT trial Randomized controlled trial Cognitive outcomes Amyloid Biomarkers ADCS

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Effects of exercise versus usual care on older adults with amnestic mild cognitive impairment: EXERT versus ADNI

Shadyab, Aladdin H, Aslanyan, Vahan, Jacobs, Diane M, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 21(4) | 2025 | Article

Topics: Mild cognitive impairment Alzheimer’s disease Exercise intervention EXERT trial ADNI Randomized controlled trial Cognitive outcomes Longitudinal Neuroimaging ADCS

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2024

Cumulative blast impulse is predictive for changes in chronic neurobehavioral symptoms following low level blast exposure during military training

McEvoy, Cory, Crabtree, Adam, Case, John, …, Thomas, Ronald G, et al. | Military medicine | 2024 | Article

Topics: Blast injury Traumatic brain injury Military health Neuroimaging Biomarkers Longitudinal Cognitive outcomes

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A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with Early Alzheimer’s Disease

Galasko, Douglas, Farlow, Martin R, Lucey, Brendan P, …, Thomas, Ronald G, et al. | Alzheimer’s Research & Therapy | vol. 16(1) | 2024 | Article

Topics: Alzheimer’s disease Randomized controlled trial Placebo-controlled Multicenter trial Pharmacokinetics Drug development Dose-finding ADCS Clinical trials

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Increased [18F] Fluorodeoxyglucose Uptake in the Left Pallidum in Military Veterans with Blast-Related Mild Traumatic Brain Injury: Potential as an Imaging Biomarker and Mediation with Executive Dysfunction and Cognitive Impairment

Terry, Garth, Pagulayan, Kathleen F, Muzi, Mark, …, Thomas, Ronald G, et al. | Journal of Neurotrauma | 2024 | Article

Topics: Traumatic brain injury Blast injury Military health Neuroimaging Biomarkers Cognitive outcomes Diagnostic testing

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Crabtree A

McEvoy C | Case J | vol. Meabon JS. Cumulative blast impulse is predictive for changes in chronic neurobehavioral symptoms following low level blast exposure during military training. Military medicine. Sep;189(9-10) | 2024 | Article

Topics: Mild cognitive impairment Alzheimer’s disease Exercise intervention EXERT trial Clinical trials Cognitive outcomes

2023

The relative contribution of COVID-19 infection versus COVID-19 related occupational stressors to insomnia in healthcare workers

Hendrickson, Rebecca C, McCall, Catherine A, Rosser, Aaron F, …, Thomas, Ronald G, et al. | Sleep medicine: X | vol. 5 | 2023 | Article

Topics: COVID-19 Sleep disorders Public health Military health Epidemiology Cognitive outcomes

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Impact of reference region on longitudinal florbetapir PET SUVR changes from the API ADAD Colombia Trial

Ghisays, Valentina, Lopera, Francisco, Su, Yi, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 19 | 2023 | Article

Topics: Alzheimer’s disease API ADAD Amyloid Neuroimaging Longitudinal Prevention trial Biomarkers Clinical trials

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Prognostic value of plasma biomarkers in a clinical trial of mild-to-moderate Alzheimer’s Disease

Qiu, Yuqi, Messer, Karen, Jacobs, Diane M, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 19 | 2023 | Article

Topics: Alzheimer’s disease Plasma biomarkers Biomarkers Clinical trials Randomized controlled trial ADCS Cognitive outcomes Biostatistics

Longitudinal Sleep Patterns and Cognitive Impairment in Older Adults

Keil, Samantha A, Schindler, Abigail G, Wang, Marie X, …, Thomas, Ronald G, et al. | JAMA Network Open | vol. 6(12) | 2023 | Article

Topics: Sleep disorders Mild cognitive impairment Aging Longitudinal Cognitive outcomes Epidemiology

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A public resource of baseline data from the Alzheimer’s Prevention Initiative Autosomal-Dominant Alzheimer’s Disease Trial

Reiman, Eric M, Pruzin, Jeremy J, Rios-Romenets, Silvia, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 19(5) | 2023 | Article

Topics: Alzheimer’s disease API ADAD Prevention trial Amyloid Biomarkers Clinical trials Medical research

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Pontine pathology mediates common symptoms of blast-induced chronic mild traumatic brain injury

Meabon, James S, Schindler, Abigail G, Murray, Daniel R, …, Thomas, Ronald G, et al. | medRxiv | 2023 | Article

Topics: Traumatic brain injury Blast injury Military health Neurodegeneration Biomarkers Neuroimaging

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A randomized controlled clinical trial of prazosin for alcohol use disorder in active duty soldiers: Predictive effects of elevated cardiovascular parameters

Raskind, Murray A, Williams, Tammy, Holmes, Hollie, …, Thomas, Ronald G, et al. | Alcoholism: Clinical and Experimental Research | vol. 47(2) | 2023 | Article

Topics: PTSD Randomized controlled trial Placebo-controlled Military health Cardiovascular disease Clinical trials VA Cooperative Studies

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Instability in longitudinal sleep duration predicts cognitive impairment in aged participants of the Seattle Longitudinal Study

Keil, Samantha A, Schindler, Abigail G, Wang, Marie X, …, Thomas, Ronald G, et al. | medRxiv | 2023 | Article

Topics: Sleep disorders Mild cognitive impairment Aging Longitudinal Cognitive outcomes Sleep Intervention Epidemiology

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Effect of Age Range on Power for a Clinical Trial Investigating the Effect of Intensive Systolic Blood Pressure Control on White Matter Hyperintensity Volume Accumulation

Pruzin, Jeremy J, Chen, Yinghua, Chen, Kewei, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 19 | 2023 | Article

Topics: Alzheimer’s disease Clinical trials Sample size Cardiovascular disease Neuroimaging Biostatistics Longitudinal Aging

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Statistical innovations in the API ADAD Colombia trial: a randomized, double-blind, placebo-controlled, parallel-group study in cognitively unimpaired PSEN1 E280A mutation carriers evaluating efficacy and safety of crenezumab

Hu, Nan, Mackey, Howard, Doody, Rachelle S, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 19 | 2023 | Article

Topics: Alzheimer’s disease API ADAD Randomized controlled trial Placebo-controlled Biostatistics Prevention trial Amyloid Clinical trials Simulation

2022

Sex differences in cognitive resilience in preclinical autosomal-dominant Alzheimer’s disease carriers and non-carriers: baseline findings from the API ADAD Colombia Trial

Vila-Castelar, Clara, Tariot, Pierre N, Sink, Kaycee M, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 18(11) | 2022 | Article

Topics: Alzheimer’s disease API ADAD Prevention trial Cognitive outcomes Neuropsychology Biostatistics Clinical trials

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The impact of the COVID-19 pandemic on mental health, occupational functioning, and professional retention among health care workers and first responders

Hendrickson, Rebecca C, Slevin, Roisı́n A, Hoerster, Katherine D, …, Thomas, Ronald G, et al. | Journal of general internal medicine | vol. 37(2) | 2022 | Article

Topics: COVID-19 PTSD Public health Military health Epidemiology Cognitive outcomes

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T2 Protect AD: Achieving a rapid recruitment timeline in a multisite clinical trial for individuals with mild to moderate Alzheimer’s disease

Shadyab, Aladdin H, LaCroix, Andrea Z, Matthews, Genevieve, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia: Translational Research & Clinical Interventions | vol. 8(1) | 2022 | Article

Topics: Alzheimer’s disease Randomized controlled trial Multicenter trial Placebo-controlled Clinical trials ADCS Drug development

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Markers of Cerebrovascular Injury, Inflammation, and Plasma Lipids Are Associated with Alzheimer’s Disease Cerebrospinal Fluid Biomarkers in Cognitively Normal Persons

Jansson, Deidre, Wang, Marie, Thomas, Ronald G, et al. | Journal of Alzheimer’s Disease | vol. 86(2) | 2022 | Article

Topics: Alzheimer’s disease Csf Biomarkers Plasma biomarkers Neuroimaging Amyloid Tau Biomarkers Cardiovascular disease

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Topline Results of EXERT: Can Exercise Slow Cognitive Decline in MCI?

Baker, Laura D, Cotman, Carl W, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 18 | 2022 | Article

Topics: Mild cognitive impairment Alzheimer’s disease Exercise intervention Cognitive outcomes Randomized controlled trial Clinical trials EXERT trial Biostatistics

2021

Power and sample size for random coefficient regression models in randomized experiments with monotone missing data

Hu, Nan, Mackey, Howard, Thomas, Ronald G | Biometrical Journal | vol. 63(4) | 2021 | Article

Topics: Biostatistics Sample size Missing data Longitudinal Mixed models Randomized controlled trial Simulation

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Amyloid and tau pathology associations with personality traits, neuropsychiatric symptoms, and cognitive lifestyle in the preclinical phases of sporadic and autosomal dominant Alzheimer’s disease

Binette, Alexa Pichet, Vachon-Presseau, Etienne, Morris, John, …, Thomas, Ronald G, et al. | Biological psychiatry | vol. 89(8) | 2021 | Article

Topics: Alzheimer’s disease API ADAD Amyloid Tau Neuropsychology Cognitive outcomes Longitudinal Biomarkers

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Rasagiline effects on glucose metabolism, cognition, and tau in Alzheimer’s dementia

Matthews, Dawn C, Ritter, Aaron, Thomas, Ronald G, et al. | Alzheimer’s & Dementia: Translational Research & Clinical Interventions | vol. 7(1) | 2021 | Article

Topics: Alzheimer’s disease Phase 2 Trial Placebo-controlled Cognitive outcomes Tau Biomarkers Drug development Clinical trials

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Recruitment of a multi-site randomized controlled trial of aerobic exercise for older adults with amnestic mild cognitive impairment: the EXERT trial

Shadyab, Aladdin, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | 2021 | Article

Topics: Mild cognitive impairment EXERT trial Exercise intervention Randomized controlled trial Multicenter trial Cognitive outcomes Clinical trials Aging

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A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease

Salloway, Stephen, Farlow, Martin, McDade, Eric, …, Thomas, Ronald G, et al. | Nature Medicine | 2021 | Article

Topics: Alzheimer’s disease API ADAD Amyloid Randomized controlled trial Placebo-controlled Drug development Clinical trials Neuroimaging

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Impact of potential modifications to Alzheimer’s disease clinical trials in response to disruption by COVID-19: a simulation study

Schneider, Lon S, Qiu, Yuqi, Thomas, Ronald G, et al. | Alzheimer’s Research & Therapy | vol. 13 | 2021 | Article

Topics: Alzheimer’s disease Clinical trials COVID-19 Simulation Missing data Longitudinal Biostatistics ADCS

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2020

Optimizing aggregated n-of-1 trial designs for predictive biomarker validation: statistical methods and theoretical findings

Hendrickson, Rebecca C, Thomas, Ronald G, Schork, Nicholas J, Raskind, Murray A | Frontiers in Digital Health | 2020 | Article

Topics: Biomarkers Biostatistics Simulation Clinical trials PTSD Military health Adaptive Design Sample size

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The Effects of Rasagiline on Glucose Metabolism and Cognition and Their Relationship to Tau Burden in a Double-Blind, Placebo-Controlled Phase Ii Clinical Trial of Participants with Alzheimer’s Dementia

Matthews, Dawn, Ritter, Aaron, Thomas, Ronald G, et al. | Placebo-Controlled Phase Ii Clinical Trial of Participants with Alzheimer’s Dementia (2/21/2020) | 2020 | Article

Topics: Alzheimer’s disease Phase 2 Trial Placebo-controlled Cognitive outcomes Tau Neuroimaging Drug development Clinical trials

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Baseline demographic, clinical, and cognitive characteristics of the Alzheimer’s Prevention Initiative (API) Autosomal-Dominant Alzheimer’s Disease Colombia Trial

Rios-Romenets, Silvia, Lopera, Francisco, Sink, Kaycee M, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 16(7) | 2020 | Article

Topics: Alzheimer’s disease API ADAD Prevention trial Randomized controlled trial Clinical trials Cognitive outcomes Longitudinal

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The Alzheimer’s Prevention Initiative Composite Cognitive Test: a practical measure for tracking cognitive decline in preclinical Alzheimer’s disease

Langbaum, Jessica B, Ellison, Noel N, Caputo, Angelika, …, Thomas, Ronald G, et al. | Alzheimer’s Research & Therapy | vol. 12 | 2020 | Article

Topics: Alzheimer’s disease API ADAD Cognitive outcomes Cognitive assessment Prevention trial Longitudinal Neuropsychology

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Sex differences in neurodegeneration and memory performance in preclinical autosomal dominant Alzheimer’s disease: Baseline findings from the API ADAD trial: Intersections of sex/gender and race/ethnicity in cognitive aging and Alzheimer’s disease trajectories

Vila-Castelar, Clara, Tariot, Pierre N, Sink, Kaycee M, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 16 | 2020 | Article

Topics: Alzheimer’s disease API ADAD Amyloid Cognitive outcomes Neuropsychology Plasma biomarkers Longitudinal Clinical trials

Development of a novel cognitive composite outcome to assess therapeutic effects of exercise in the EXERT trial for adults with MCI: The ADAS-Cog-Exec

Jacobs, Diane M, Thomas, Ronald G, et al. | Alzheimer’s & Dementia: Translational Research & Clinical Interventions | vol. 6(1) | 2020 | Article

Topics: Mild cognitive impairment EXERT trial Exercise intervention Cognitive outcomes Cognitive assessment Randomized controlled trial Clinical trials Biostatistics

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C., Tariot, P.N., Sink, K.M., Clayton, D., Langbaum, J.B., Thomas, R.G., Chen, Y., Su, Y., Hu, N., Giraldo-Chica, M., Tobon, C., Acosta-Baena, N., Luna-Maldonado, E., Londoño, M., Ospina, P., Tirado, V., Muñoz, C., Henao, E., Bocanegra, Y., Alvarez, S., Rios-Romenets, S., Ghisays, V., Goradia, D.D., Lee, W., Luo, J., Malek-Ahmadi, M.H., Protas, H.D., Lopera, F., Reiman, E.M., Quiroz, Y.T.

Vila-Castelar | API ADAD Colombia Trial Group. (). Sex differences in neurodegeneration and memory performance in preclinical autosomal dominant alzheimer’s disease: Baseline findings from the API ADAD trial: Intersections of sex/gender and race/ethnicity in cognitive aging and alzheimer’s disease trajectories. Alzheimer’s & Dementia | vol. 16 | 2020 | Article

Topics: Alzheimer’s disease API ADAD Prevention trial Clinical trials Neuroimaging Biomarkers Epidemiology Biostatistics

Lopera F, Goradia DD, Protas HD, Malek-Ahmadi MH, Chen Y, Devadas V, Luo J, Lee W, Baena A, Bocanegra Y, Guzmán-Vélez E, Pardilla-Delgado E, Vila-Castelar C, Fox-Fuller JT, Hu N, Clayton D, Thomas RG, Alvarez S, Espinosa A, Acosta-Baena N, Giraldo MM, Rios-Romenets S, Langbaum JB, Chen K, Su Y, Tariot PN, Quiroz YT

Ghisays V | Reiman EM; API ADAD Colombia Trial Group.. (). PET evidence of preclinical cerebellar amyloid plaque deposition in autosomal dominant alzheimer’s disease: Neuroimaging/imaging and genetics. Alzheimer’s & Dementia | vol. 16 | 2020 | Article

Topics: Alzheimer’s disease API ADAD Prevention trial Amyloid Neuroimaging Plasma biomarkers Biomarkers Clinical trials Biostatistics

2019

Memantine and acetylcholinesterase inhibitor use in Alzheimer’s disease clinical trials: Potential for confounding by indication

Huisa, Branko N, Thomas, Ronald G, Jin, Shelia, Oltersdorf, Tilman, Taylor, Curtis, Feldman, Howard H | Journal of Alzheimer’s Disease | vol. 67(2) | 2019 | Article

Topics: Alzheimer’s disease Clinical trials Drug development ADCS Cognitive outcomes Biostatistics Missing data

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A randomized clinical trial to evaluate home-based assessment of people over 75 years old

Sano, Mary, Zhu, Carolyn W, Kaye, Jeffrey, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 15(5) | 2019 | Article

Topics: Alzheimer’s disease Randomized controlled trial Cognitive outcomes Aging Longitudinal ADCS Clinical trials

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The Alzheimer’s Prevention Initiative Generation Program: study design of two randomized controlled trials for individuals at risk for clinical onset of Alzheimer’s disease

Lopez, Cristina Lopez, Tariot, Pierre N, Caputo, Angelika, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia: Translational Research & Clinical Interventions | vol. 5 | 2019 | Article

Topics: Alzheimer’s disease Prevention trial Randomized controlled trial API ADAD Clinical trials Amyloid Drug development Multicenter trial

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Safety and efficacy of edonerpic maleate for patients with mild to moderate Alzheimer disease: a phase 2 randomized clinical trial

Schneider, Lon S, Thomas, Ronald G, et al. | JAMA neurology | vol. 76(11) | 2019 | Article

Topics: Alzheimer’s disease Phase 2 Trial Randomized controlled trial Placebo-controlled Clinical trials Drug development ADCS Cognitive outcomes

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New Perspective for Non-invasive Brain Stimulation Site Selection in Mild Cognitive Impairment: Based on Meta-and Functional Connectivity Analyses

Liu, Jiao, Zhang, Binlong, Wilson, Georgia, …, Thomas, Ronald G, et al. | Frontiers in aging neuroscience | vol. 11 | 2019 | Article

Topics: Mild cognitive impairment Neuroimaging Cognitive assessment Meta Analysis ADNI Biomarkers

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Low-dose ladostigil for mild cognitive impairment: A phase 2 placebo-controlled clinical trial

Schneider, Lon S, Geffen, Yona, Rabinowitz, Jonathan, …, Thomas, Ronald G, et al. | Neurology | vol. 93(15) | 2019 | Article

Topics: Mild cognitive impairment Phase 2 Trial Placebo-controlled Randomized controlled trial Clinical trials Drug development Cognitive outcomes

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F4-04-02: AGE-RELATED CHANGES IN BASELINE COGNITIVE MEASURES IN UNIMPAIRED PSEN1 E280A MUTATION CARRIERS AND NON-CARRIERS IN THE API AUTOSOMAL DOMINANT ALZHEIMER’S DISEASE COLOMBIA TRIAL

Acosta-Baena, Natalia, Rios-Romenets, Silvia, Munoz, Claudia, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 15 | 2019 | Article

Topics: Alzheimer’s disease API ADAD Cognitive outcomes Cognitive assessment Prevention trial Clinical trials Longitudinal

F4-04-03: RELATIONSHIPS BETWEEN BASELINE BRAIN IMAGING BIOMARKER MEASUREMENTS AND AGE IN THE API AUTOSOMAL DOMINANT ALZHEIMER’S DISEASE COLOMBIA TRIAL

Su, Yi, Rios-Romenets, Silvia, Tariot, Pierre N, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 15 | 2019 | Article

Topics: Alzheimer’s disease API ADAD Neuroimaging Amyloid Biomarkers Prevention trial Clinical trials

F4-04-01: TRIAL DESIGN, DATA SHARING RISK MITIGATION, AND BASELINE CLINICAL AND COGNITIVE DATA FROM THE API AUTOSOMAL DOMINANT ALZHEIMER’S DISEASE COLOMBIA TRIAL

Tariot, Pierre N, Lopera, Francisco, Sink, Kaycee, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 15 | 2019 | Article

Topics: Alzheimer’s disease API ADAD Randomized controlled trial Prevention trial Clinical trials Cognitive outcomes Multicenter trial

C. L., Tariot, P. N., Caputo, A., Langbaum, J. B., Liu, F., Riviere, M.-E., Langlois, C., Rouzade-Dominguez, M.-L., Zalesak, M., Hendrix, S., Thomas, R. G., Viglietta, V., Lenz, R., Ryan, J. M., Graf, A., Reiman

Lopez | E. M. (). The alzheimer’s prevention initiative generation program: Study design of two randomized controlled trials for individuals at risk for clinical onset of alzheimer’s disease. Alzheimer’s & Dementia: Translational Research & Clinical Interventions | vol. 5 | 2019 | Article

Topics: Alzheimer’s disease Prevention trial API ADAD Randomized controlled trial Placebo-controlled Clinical trials Biostatistics Drug development Sample size

N., Rios-Romenets, S., Muñoz, C., Bocanegra, Y., Henao, E., Giraldo, M., Tobon, C., Sink, K., Hu, N., Guthrie

Acosta-Baena | H.others. (). F4-04-02: AGE-RELATED CHANGES IN BASELINE COGNITIVE MEASURES IN UNIMPAIRED PSEN1 E280A MUTATION CARRIERS AND NON-CARRIERS IN THE API AUTOSOMAL DOMINANT ALZHEIMER’s DISEASE COLOMBIA TRIAL. Alzheimer’s & Dementia | vol. 15 | 2019 | Article

Topics: Alzheimer’s disease Cognitive assessment Cognitive outcomes API ADAD Prevention trial Aging Longitudinal

Y., Rios-Romenets, S., Tariot, P. N., Sink, K., Clayton, D., Hu, N., Guthrie, H., Smith, J., Cho, W., Langbaum

Su | J. B.others. (). F4-04-03: RELATIONSHIPS BETWEEN BASELINE BRAIN IMAGING BIOMARKER MEASUREMENTS AND AGE IN THE API AUTOSOMAL DOMINANT ALZHEIMER’s DISEASE COLOMBIA TRIAL. Alzheimer’s & Dementia | vol. 15 | 2019 | Article

Topics: Alzheimer’s disease Neuroimaging Amyloid Biomarkers API ADAD Prevention trial Cognitive outcomes

P. N., Lopera, F., Sink, K., Hu, N., Guthrie, H., Smith, J., Cho, W., Langbaum, J. B., Thomas, R. G., Giraldo, M.others. (). F4-04-01: TRIAL DESIGN, DATA SHARING RISK MITIGATION

Tariot | AND BASELINE CLINICAL AND COGNITIVE DATA FROM THE API AUTOSOMAL DOMINANT ALZHEIMER’s DISEASE COLOMBIA TRIAL. Alzheimer’s & Dementia | vol. 15 | 2019 | Article

Topics: Alzheimer’s disease Prevention trial Clinical trials API ADAD Cognitive outcomes Amyloid Randomized controlled trial Multicenter trial

Y. T., Tariot, P. N., Sink, K., Clayton, D., Langbaum, J. B., Thomas, R. G., Giraldo, M., Tobon, C., Acosta-Baena, N., Luna

Quiroz | E.others. (). F4-04-04: ASSOCIATION BETWEEN CEREBRAL AMYLOIDOSIS AND WORSE COGNITIVE PERFORMANCE IN PRECLINICAL AUTOSOMAL DOMINANT ALZHEIMER’s DISEASE: BASELINE FINDINGS FROM THE API COLOMBIA AUTOSOMAL DOMINANT AD TRIAL. Alzheimer’s & Dementia | vol. 15 | 2019 | Article

Topics: Alzheimer’s disease Amyloid Cognitive outcomes API ADAD Prevention trial Neuroimaging Biomarkers

2018

Adeno-associated viral vector (serotype 2)–nerve growth factor for patients with alzheimer disease: a randomized clinical trial

Rafii, Michael S, Tuszynski, Mark H, Thomas, Ronald G, et al. | JAMA neurology | vol. 75(7) | 2018 | Article

Topics: Alzheimer’s disease Randomized controlled trial ADCS Drug development Clinical trials Cognitive outcomes Biomarkers

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The Alzheimer’s Prevention Initiative Autosomal-Dominant Alzheimer’s Disease Trial: A study of crenezumab versus placebo in preclinical PSEN1 E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal-dominant Alzheimer’s disease, including a placebo-treated noncarrier cohort

Tariot, Pierre N, Lopera, Francisco, Langbaum, Jessica B, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia: Translational Research & Clinical Interventions | vol. 4 | 2018 | Article

Topics: Alzheimer’s disease Prevention trial API ADAD Placebo-controlled Randomized controlled trial Amyloid Clinical trials Drug development Phase 3 Trial

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P3-032: SCREENING-TO-BASELINE COGNITIVE VARIABILITY DOES NOT PREDICT RATE OF DECLINE IN A CLINICAL TRIAL OF MILD-TO-MODERATE AD

Jacobs, Diane M, Thomas, Ronald G, Salmon, David P, Huisa, Branko N, Feldman, Howard H, Schneider, Lon S | Alzheimer’s & Dementia | vol. 14(7S_Part_20) | 2018 | Article

Topics: Alzheimer’s disease Clinical trials Cognitive outcomes ADCS Neuropsychology Longitudinal Biostatistics

P4-209: A PUBLIC RESOURCE OF BASELINE DATA FROM THE API AUTOSOMAL DOMINANT ALZHEIMER’S DISEASE COLOMBIA TRIAL

Reiman, Eric M, Sink, Kaycee M, Hu, Nan, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 14(7S_Part_29) | 2018 | Article

Topics: Alzheimer’s disease Prevention trial API ADAD Clinical trials Amyloid Biomarkers Placebo-controlled Longitudinal

Tuszynski MH, Thomas RG, Barba D, Brewer JB, Rissman RA, Siffert J, Aisen PS. Adeno-associated viral vector (serotype 2)–nerve growth factor for patients with Alzheimer disease: a randomized clinical trial

Rafii MS | JAMA neurology | vol. 75 | 2018 | Article

Topics: Alzheimer’s disease Randomized controlled trial Clinical trials ADCS Drug development Phase 2 Trial

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Thomas RG, Salmon DP, Huisa BN, Feldman HH, and Schneider LS. SCREENING-TO-BASELINE COGNITIVE VARIABILITY DOES NOT PREDICT RATE OF DECLINE IN A CLINICAL TRIAL OF MILD-TO-MODERATE AD

Jacobs DM | Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association | vol. 14 | 2018 | Article

Topics: Alzheimer’s disease Clinical trials Cognitive outcomes Cognitive assessment Longitudinal Biostatistics ADCS

Sink KM, Hu N, Guthrie H, Smith J, Cho W, Knoll KL, Langbaum JB, Thomas RG, Toga AW, Chen K, Boker CA, Alvarez S, Quiroz YT, Rios Romenets S, Lopera F, Pierre NT

Reiman EM | API ADAD Columbia Study Group. A PUBLIC RESOURCE OF BASELINE DATA FROM THE API AUTOSOMAL DOMINANT ALZHEIMER’S DISEASE COLOMBIA TRIAL Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association | vol. 14 | 2018 | Article

Topics: Alzheimer’s disease Prevention trial Amyloid Neuroimaging Plasma biomarkers API ADAD Cognitive outcomes Biomarkers

2017

A phase 3 trial of IV immunoglobulin for Alzheimer disease

Relkin, Norman R, Thomas, Ronald G, et al. | Neurology | vol. 88(18) | 2017 | Article

Topics: Alzheimer’s disease Phase 3 Trial Randomized controlled trial Placebo-controlled Drug development ADCS Clinical trials Biomarkers

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Randomized controlled trials in mild cognitive impairment: sources of variability

Petersen, Ronald C, Thomas, Ronald G, et al. | Neurology | vol. 88(18) | 2017 | Article

Topics: Mild cognitive impairment Randomized controlled trial ADNI ADCS Biostatistics Sample size Missing data Cognitive assessment Clinical trials

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The Alzheimer’s Prevention Initiative Generation Program: evaluating CNP520 efficacy in the prevention of Alzheimer’s disease

Lopez, C Lopez, Caputo, A, Liu, F, …, Thomas, Ronald G, et al. | J Prev Alzheimers Dis | vol. 4(4) | 2017 | Article

Topics: Alzheimer’s disease Prevention trial API ADAD Clinical trials Drug development Amyloid Cognitive outcomes Biomarkers

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Thomas RG, Aisen PS, Mohs RC, Carrillo MC, Albert MS, Alzheimer’s Disease Neuroimaging Initiative (ADNI), and Foundation for NIH (FNIH) Biomarkers Consortium AD MCI Placebo Data Analysis Project Team. Randomized controlled trials in mild cognitive impairment: Sources of variability

Petersen RC | Neurology | vol. 88 | 2017 | Article

Topics: Alzheimer’s disease Mild cognitive impairment ADNI ADCS Biomarkers Clinical trials

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Thomas RG, Rissman RA, Brewer JB, Rafii MS, Van Dyck CH, Jack CR, Sano M, Knopman DS, Raman R, Szabo P, Gelmont DM, Fritsch S, Aisen PS, Alzheimer’s Disease Cooperative Study. A phase 3 trial of IV immunoglobulin for Alzheimer disease

Relkin NR | Neurology | vol. 88 | 2017 | Article

Topics: Alzheimer’s disease Phase 3 Trial Placebo-controlled Randomized controlled trial ADCS Drug development Clinical trials

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Caputo A, Liu F, Riviere ME, Rouzade-Dominguez ML, Thomas RG, Langbaum JB, Lenz R, Reiman EM, Graf A, Tariot PN. The Alzheimer’s prevention initiative generation program: evaluating CNP520 efficacy in the prevention of Alzheimer’s disease

Lopez-Lopez C | The journal of prevention of Alzheimer’s disease | vol. 4 | 2017 | Article

Topics: Alzheimer’s disease Prevention trial API ADAD Placebo-controlled Clinical trials Drug development Amyloid

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Thomas RG, Hendrix S, Brewer JB, Rissman RA, Salmon DP, Kobayashi H, Feldman HH. A Phas 2 Multicenter, Randomized

Schneider LS | Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Edonerpic (T-817) in Patients with Mild to Moderate Alzheimer’s Disease. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association | vol. 13 | 2017 | Article

Topics: Alzheimer’s disease Phase 2 Trial Multicenter trial Randomized controlled trial Placebo-controlled Clinical trials Drug development Biostatistics Cognitive outcomes

Racine A, Paule I, Martens EP, Tariot P, Langbaum JB, Thomas RG, Hendrix S, Ryan JM, Lopez-Lopez C, Graf A. Rationale for selection of primary endpoints in the Alzheimer Prevention Initiative Generation study in cognitively healthy APOE4 homozygotes

Caputo A | Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association | vol. 13 | 2017 | Article

Topics: Alzheimer’s disease Prevention trial API ADAD Clinical trials Cognitive outcomes Biostatistics Sample size

Lopez-Lopez C, Caputo A, Thomas RG, Langbaum J, Lenz R, Vargas G, Viglietta V, Reiman EM, Graf, A

Tariot P | The Alzheimer’s Prevention Initiative (API) Generation Program: Evaluating the Efficacy of the BACE-1 Inhibitor CNP520 in Preclinical Alzheimer’s Disease. NATURE NEUROPSYCHOPHARMACOLOGY | vol. 42 | 2017 | Article

Topics: Alzheimer’s disease Prevention trial API ADAD Clinical trials Randomized controlled trial Biostatistics Cognitive outcomes Drug development

2016

Longitudinal decline in mild-to-moderate Alzheimer’s disease: analyses of placebo data from clinical trials

Thomas, Ronald G, Albert, Marilyn, Petersen, Ronald C, Aisen, Paul S | Alzheimer’s & Dementia | vol. 12(5) | 2016 | Article

Topics: Alzheimer’s disease Longitudinal Clinical trials Placebo-controlled Cognitive outcomes Biostatistics Mixed models ADCS

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Demonstration of safety of intravenous immunoglobulin in geriatric patients in a long-term, placebo-controlled study of Alzheimer’s disease

Gelmont, David, Thomas, Ronald G, et al. | Alzheimer’s & Dementia: Translational Research & Clinical Interventions | vol. 2(2) | 2016 | Article

Topics: Alzheimer’s disease Dementia Placebo-controlled Clinical trials ADCS Drug development Aging Biostatistics

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Thomas RG, Britt J, Dyck-Jones JA, Doralt J, Fritsch S, Brewer JB, Rissman RA, and Aisen P. Demonstration of safety of intravenous immunoglobulin in geriatric patients in a long-term, placebo-controlled study of Alzheimer’s disease

Gelmont D | Alzheimer’s & Dementia: Translational Research & Clinical Interventions | vol. 2 | 2016 | Article

Topics: Alzheimer’s disease Placebo-controlled Clinical trials ADCS Drug development Randomized controlled trial

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Langbaum J, Schneider L, Thomas RG, Graf A, Lopez-Lopez Cristina, Caputo A, Lenz R, Vargas G, Reiman EM, The Alzheimer’s Prevention Initiative Generation Study: A Preclinical Trial in APOE4 Homozygotes

Tariot P | NEUROPSYCHOPHARMACOLOGY | vol. 41 | 2016 | Article

Topics: Alzheimer’s disease Prevention trial API ADAD Placebo-controlled Clinical trials Neuroimaging Biostatistics Amyloid

2015

Longitudinal plasma amyloid beta in Alzheimer’s disease clinical trials

Donohue, Michael C, Moghadam, Setareh H, Roe, Allyson D, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 11(9) | 2015 | Article

Topics: Alzheimer’s disease Plasma biomarkers Amyloid Clinical trials Longitudinal ADNI ADCS Mixed models

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Peripheral and central effects of \γ-secretase inhibition by semagacestat in Alzheimer’s disease

Doody, Rachelle S, Raman, Rema, Sperling, Reisa A, …, Thomas, Ronald G, et al. | Alzheimer’s research & therapy | vol. 7(1) | 2015 | Article

Topics: Alzheimer’s disease Dementia Phase 3 Trial Drug development ADCS Clinical trials Pharmacokinetics Biomarkers

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A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

Turner, R Scott, Thomas, Ronald G, et al. | Neurology | vol. 85(16) | 2015 | Article

Topics: Alzheimer’s disease Dementia Randomized controlled trial Placebo-controlled Clinical trials ADCS Drug development Biostatistics

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Thomas RG, Dyck-Jones JA, Fritsch S, Aisen P, Relkin, N. Safety of Intravenous Immunoglobulin Therapy in Patients with Probable Alzheimer’s Disease: A Randomized

Gelmont D | Placebo-Controlled Clinical Study | vol. 115 | 2015 | Article

Topics: Alzheimer’s disease Randomized controlled trial Placebo-controlled Clinical trials Drug development Biostatistics ADCS

2014

Phase 3 trials of solanezumab for mild-to-moderate Alzheimer’s disease

Doody, Rachelle S, Thomas, Ronald G, et al. | New England Journal of Medicine | vol. 370(4) | 2014 | Article

Topics: Alzheimer’s disease Phase 3 Trial Placebo-controlled Amyloid Drug development Clinical trials Randomized controlled trial

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Clinical trial of an inhibitor of RAGE-A beta interactions in Alzheimer disease

Galasko, Douglas, Bell, Joanne, Mancuso, Jessica Y, …, Thomas, Ronald G, et al. | Neurology | vol. 82(17) | 2014 | Article

Topics: Alzheimer’s disease Randomized controlled trial Placebo-controlled Clinical trials Amyloid Drug development ADCS

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The preclinical Alzheimer cognitive composite: measuring amyloid-related decline

Donohue, Michael C, Sperling, Reisa A, Salmon, David P, …, Thomas, Ronald G, et al. | JAMA neurology | vol. 71(8) | 2014 | Article

Topics: Alzheimer’s disease Mild cognitive impairment Amyloid Cognitive outcomes Biomarkers Prevention trial ADNI Longitudinal

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Estimating long-term multivariate progression from short-term data

Donohue, Michael C, Jacqmin-Gadda, Hene, Le Goff, Melanie, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 10 | 2014 | Article

Topics: Alzheimer’s disease Longitudinal Mixed models Biostatistics ADNI Cognitive outcomes Missing data

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P1-357: ADCS EDC: INVESTIGATIONAL PRODUCT MANAGEMENT SYSTEM

Jimenez-Maggiora, Gustavo Adolfo, Thomas, Ronald G, Qiu, Hongmei, Hong, Phuoc, Aisen, Paul S | Alzheimer’s & Dementia | vol. 10 | 2014 | Article

Topics: ADCS Clinical trials Alzheimer’s disease Medical research Healthcare analytics

Phase 3 trials of solanezumab and bapineuzumab for Alzheimer’s disease

Laske, Christoph | N Engl J Med | vol. 370(15) | 2014 | Article

Topics: Alzheimer’s disease Dementia Phase 3 Trial Amyloid Clinical trials Drug development ADCS Placebo-controlled

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M. C., Gamst, A., Jack, C., Beckett, L., Weiner, M., Aisen, P., Raman, R., & Thomas

Donohue | R. (). F3-02-02: MODELING LONG-TERM DISEASE PROGRESSION WITH COVARIATES. Alzheimer’s & Dementia | vol. 10 | 2014 | Article

Topics: Alzheimer’s disease Longitudinal Mixed models Cognitive outcomes Neuroimaging Simulation ADNI

G. A., Thomas, R. G., Qiu, H., Bruschi, S., So, J.-S., Hong, P., & Aisen

Jimenez-Maggiora | P. S. (). P1-358: ADCS EDC: DATA EXCHANGE AND PROCESSING PLATFORM. Alzheimer’s & Dementia | vol. 10 | 2014 | Article

Topics: Alzheimer’s disease Clinical trials ADCS Healthcare analytics Medical research

2013

A phase 3 trial of semagacestat for treatment of Alzheimer’s disease

Doody, Rachelle S, Raman, Rema, Farlow, Martin, …, Thomas, Ronald G, et al. | New England Journal of Medicine | vol. 369(4) | 2013 | Article

Topics: Alzheimer’s disease Phase 3 Trial Randomized controlled trial Placebo-controlled Drug development ADCS Clinical trials

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Putting the Alzheimer’s cognitive test to the test II: Rasch Measurement Theory

Hobart, Jeremy, Cano, Stefan, Posner, Holly, …, Thomas, Ronald G, et al. | Alzheimer’s & dementia | vol. 9(1S) | 2013 | Article

Topics: Alzheimer’s disease Cognitive outcomes Cognitive assessment ADNI Neuropsychology Biostatistics

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Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial

Mills, Sarah M, Mallmann, J, Santacruz, Anna M, …, Thomas, Ronald G, et al. | Revue neurologique | vol. 169(10) | 2013 | Article

Topics: Alzheimer’s disease API ADAD Amyloid Randomized controlled trial Prevention trial Clinical trials Drug development Biomarkers

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Age and apolipoprotein E genotype influence rate of cognitive decline in nondemented elderly.

Salmon, David P, Ferris, Steven H, Thomas, Ronald G, et al. | Neuropsychology | vol. 27(4) | 2013 | Article

Topics: Alzheimer’s disease Cognitive outcomes Aging Neuropsychology Longitudinal Biomarkers Epidemiology

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Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer’s disease and its precursors: a new approach

Posner, Holly B, Cano, Stefan, Carrillo, Maria C, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 9(1) | 2013 | Article

Topics: Alzheimer’s disease Mild cognitive impairment Cognitive assessment Cognitive outcomes Clinical trials Biostatistics ADNI

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P1–332: Evaluation of the relationship between TTP488 plasma concentrations and changes in ADAS-cog relative to placebo

Burstein, Aaron, Galasko, Douglas, Aisen, Paul, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 9 | 2013 | Article

Topics: Alzheimer’s disease Clinical trials Pharmacokinetics Plasma biomarkers Cognitive outcomes ADCS

P3–295: The Placebo Data Analysis in Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI) Clinical Trials Project: Overview of progress in trial data collection, and key findings from the pooled Alzheimer’s disease trial datasets

Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 9 | 2013 | Article

Topics: Alzheimer’s disease Mild cognitive impairment Clinical trials Placebo-controlled ADCS ADNI Missing data Longitudinal

Cano Stefan

Posner B. Holly | Carrillo Maria C. | vol. Hobart Jeremy; for the Alzheimer’s Disease Neuroimaging Initiative; Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer’s Disease and its precursors | 2013 | Article

Topics: Alzheimer’s disease Clinical trials Cognitive outcomes ADCS Biomarkers

G., Thomas, R., Brewer, J., Bruschi, S., Hong, P., & Aisen

Jimenez-Maggiora | P. (). P4–184: ADCS electronic data capture: Integrated image management. Alzheimer’s & Dementia | vol. 9 | 2013 | Article

Topics: Alzheimer’s disease Clinical trials ADCS Healthcare analytics Medical research

A., Galasko, D., Aisen, P., Thomas, R., Grimes, I., Clark, D. J., Mjalli, A., & Orlande

Burstein | C. (). P1–332: Evaluation of the relationship between TTP488 plasma concentrations and changes in ADAS-cog relative to placebo. Alzheimer’s & Dementia | vol. 9 | 2013 | Article

Topics: Alzheimer’s disease Clinical trials Pharmacokinetics Plasma biomarkers ADCS Biomarkers

R., Petersen, R., Siuciak, J., Carrillo, M., Albert, M., Aisen, P., Initiative, A. D. N., & NIH Biomarkers Consortium AD MCI Placebo Data Project Team, F. for. (). P3–295: The placebo data analysis in alzheimer’s disease (AD) and mild cognitive impairment (MCI) clinical trials project: Overview of progress in trial data collection

Thomas | and key findings from the pooled alzheimer’s disease trial datasets. Alzheimer’s & Dementia | vol. 9 | 2013 | Article

Topics: Alzheimer’s disease Mild cognitive impairment Clinical trials Placebo-controlled Biomarkers ADNI Missing data Biostatistics

2012

Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures

Galasko, Douglas R, Peskind, Elaine, Clark, Christopher M, …, Thomas, Ronald G, et al. | Archives of neurology | vol. 69(7) | 2012 | Article

Topics: Alzheimer’s disease Randomized controlled trial Csf Biomarkers Biomarkers Placebo-controlled Clinical trials ADCS

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Incidence of new-onset seizures in mild to moderate Alzheimer disease

Irizarry, Michael C, Jin, Shelia, He, Feng, …, Thomas, Ronald G, et al. | Archives of neurology | vol. 69(3) | 2012 | Article

Topics: Alzheimer’s disease Mild cognitive impairment Clinical trials Epidemiology Biostatistics ADCS

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Alzheimer’s disease therapeutic trials: EU/US Task Force report on recruitment, retention, and methodology

Vellas, B, Hampel, H, Rougé-Bugat, ME, …, Thomas, Ronald G, et al. | The journal of nutrition, health & aging | vol. 16(4) | 2012 | Article

Topics: Alzheimer’s disease Clinical trials Multicenter trial Drug development Medical research ADCS Sample size

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O3-13-05: The Gammaglobulin Alzheimer Partnership Study (GAP): Design, screening, enrollment and futility analysis results

Relkin, Norman, Gessert, Devon, Stokes, Karen, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 8(4S_Part_12) | 2012 | Article

Topics: Alzheimer’s disease Randomized controlled trial Placebo-controlled Clinical trials ADCS Adaptive Design Drug development

P3-364: ADCS EDC

Jimenez-Maggiora, Gustavo, Thomas, Ronald G, Hong, Phuoc, Aisen, Paul | Alzheimer’s & Dementia | vol. 8(4S_Part_16) | 2012 | Article

Topics: Alzheimer’s disease Clinical trials ADCS Healthcare analytics Medical research

P3-384: The placebo data analysis in Alzheimer’s disease and mild cognitive impairment (MCI) clinical trials project: Overview of progress in trial data collection, and key findings from the pooled MCI trial datasets

Aisen, Paul, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 8(4S_Part_16) | 2012 | Article

Topics: Alzheimer’s disease Mild cognitive impairment Clinical trials Placebo-controlled ADCS Missing data Longitudinal

P3-383: ADCS data sharing

Thomas, Ronald G, Jimenez, Gustavo, Brewer, James, Rissman, Robert A, Aisen, Paul | Alzheimer’s & Dementia | vol. 8(4S_Part_16) | 2012 | Article

Topics: Alzheimer’s disease ADCS Clinical trials Medical research Biostatistics

Alzheimer’s Disease Cooperative Study. Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures

Galasko, DR, Peskind, E, Clark, CM, …, Thomas, Ronald G, et al. | Arch Neurol | vol. 69(7) | 2012 | Article

Topics: Alzheimer’s disease Randomized controlled trial Csf Biomarkers Placebo-controlled Clinical trials ADCS Biomarkers

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2011

A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease

Sano, M, Bell, KL, Galasko, D, …, Thomas, Ronald G, et al. | Neurology | vol. 77(6) | 2011 | Article

Topics: Alzheimer’s disease Dementia Randomized controlled trial Placebo-controlled Clinical trials Drug development Cognitive outcomes ADCS

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Report of the task force on designing clinical trials in early (predementia) AD

Aisen, PS, Andrieu, S, Sampaio, C, …, Thomas, Ronald G, et al. | Neurology | vol. 76(3) | 2011 | Article

Topics: Alzheimer’s disease Mild cognitive impairment Clinical trials Prevention trial Drug development Adaptive Design Biomarkers ADCS

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A phase II trial of huperzine A in mild to moderate Alzheimer disease

Rafii, MS, Walsh, S, Little, JT, …, Thomas, Ronald G, et al. | Neurology | vol. 76(16) | 2011 | Article

Topics: Alzheimer’s disease Phase 2 Trial Clinical trials Drug development Cognitive outcomes ADCS Placebo-controlled

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Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease

Tariot, Pierre N, Schneider, Lon S, Cummings, Jeffrey, …, Thomas, Ronald G, et al. | Archives of General Psychiatry | vol. 68(8) | 2011 | Article

Topics: Alzheimer’s disease Dementia Randomized controlled trial Placebo-controlled Clinical trials Drug development ADCS Cognitive outcomes

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Chronic divalproex sodium use and brain atrophy in Alzheimer disease

Fleisher, AS, Truran, D, Mai, JT, …, Thomas, Ronald G, et al. | Neurology | vol. 77(13) | 2011 | Article

Topics: Alzheimer’s disease Clinical trials Randomized controlled trial Neuroimaging Biostatistics ADCS

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Adding delayed recall to the Alzheimer Disease Assessment Scale is useful in studies of mild cognitive impairment but not Alzheimer disease

Sano, Mary, Raman, Rema, Emond, Jennifer, …, Thomas, Ronald G, et al. | Alzheimer disease and associated disorders | vol. 25(2) | 2011 | Article

Topics: Alzheimer’s disease Mild cognitive impairment Cognitive assessment Cognitive outcomes Clinical trials ADCS Biostatistics

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Dietary self-monitoring and its impact on weight loss in overweight children

Mockus, Danyte S, Macera, Caroline A, Wingard, Deborah L, Peddecord, Michael, Thomas, Ronald G, Wilfley, Denise E | International Journal of Pediatric Obesity | vol. 6(3-4) | 2011 | Article

Topics: Public health Medical research Epidemiology Healthcare analytics Longitudinal

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The relative efficiency of time-to-threshold and rate of change in longitudinal data

Donohue, Michael C, Gamst, AC, Thomas, Ronald G, et al. | Contemporary clinical trials | vol. 32(5) | 2011 | Article

Topics: Alzheimer’s disease Longitudinal Biostatistics Sample size ADNI Clinical trials Cognitive outcomes

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P3-406: Role of caregiver in subject’s compliance with treatment

Messick, Viviana, Donohue, Michael, Raman, Rema, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 7 | 2011 | Article

Topics: Alzheimer’s disease Clinical trials ADCS Randomized controlled trial Functional outcomes Longitudinal

Radiological follow up of perineal repair with cross-linked acellular porcine dermal collagen following extralevator abdominoperineal excision for low rectal cancer: P115

Smart, N, George, A, Khan, D, Thomas, Ronald G, Daniels, I | Colorectal Disease | vol. 13 | 2011 | Article

Topics: Cancer Biomarkers Medical research Clinical trials Colorectal surgery

2010

Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial

Quinn, Joseph F, Raman, Rema, Thomas, Ronald G, et al. | Jama | vol. 304(17) | 2010 | Article

Topics: Alzheimer’s disease Randomized controlled trial Placebo-controlled ADCS Clinical trials Cognitive outcomes Drug development

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Clinical Core of the Alzheimer’s Disease Neuroimaging Initiative: progress and plans

Aisen, Paul S, Petersen, Ronald C, Donohue, Michael C, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 6(3) | 2010 | Article

Topics: Alzheimer’s disease Mild cognitive impairment ADNI Neuroimaging Cognitive outcomes Biomarkers Longitudinal

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P1-447: Cerebrospinal fluid biomarker outcomes in a trial of docosahexaenoic acid (DHA) for Alzheimer’s disease

Quinn, Joseph F, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 6 | 2010 | Article

Topics: Alzheimer’s disease Csf Biomarkers Clinical trials Placebo-controlled ADCS Biomarkers Pharmacokinetics

O3-01-07: Rate of decline in ADNI normal controls with evidence of amyloid burden

Donohue, Michael, Gamst, Anthony, Thomas, Ronald G, Brewer, Jim, Weiner, Michael, Aisen, Paul | Alzheimer’s & Dementia | vol. 6 | 2010 | Article

Topics: Alzheimer’s disease Mild cognitive impairment ADNI Amyloid Longitudinal Cognitive outcomes Biomarkers

Dickerson BC; Alzheimer’s Disease Neuroimaging Initiative. Collaborators (194) Weiner M

Wolk DA | Aiello M | vol. Zimmerman EA. Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer’s disease. Proc Natl Acad Sci U S A. Jun 1; 107(22) | 2010 | Article

Topics: Alzheimer’s disease Mild cognitive impairment ADNI Neuroimaging Amyloid Biomarkers Longitudinal Cognitive outcomes

2009

Plasma urate and progression of mild cognitive impairment

Irizarry, Michael C, Raman, Rema, Schwarzschild, Michael A, …, Thomas, Ronald G, et al. | Neurodegenerative Diseases | vol. 6(1-2) | 2009 | Article

Topics: Mild cognitive impairment Alzheimer’s disease Plasma biomarkers Biomarkers Longitudinal Cognitive outcomes ADCS

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O1-04-02: A clinical trial of docosahexanoic acid (DHA) for the treatment of Alzheimer’s disease

Quinn, Joseph F, Raman, Rema, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 5(4S_Part_3) | 2009 | Article

Topics: Alzheimer’s disease Clinical trials Randomized controlled trial Cognitive outcomes ADCS Drug development

O1-04-03: The ADCS valproate neuroprotection trial: Primary efficacy and safety results

Tariot, Pierre N, Aisen, Paul, Cummings, Jeffrey, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 5(4S_Part_3) | 2009 | Article

Topics: Alzheimer’s disease Clinical trials Randomized controlled trial Placebo-controlled ADCS Drug development Biostatistics

MRI substudy participation in Alzheimer disease (AD) clinical trials: baseline comparability of a substudy sample to entire study population

Raman, Rema, Thomas, Ronald G, et al. | Alzheimer disease and associated disorders | vol. 23(4) | 2009 | Article

Topics: Alzheimer’s disease Neuroimaging Clinical trials ADCS Biomarkers Multicenter trial

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P1-270: The ADAS-cog’s performance as a measure-lessons from the ADNI study: Part 3-do the scale modifications add value?

Hobart, Jeremy, Posner, Holly, Aisen, Paul, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 5(4S_Part_9) | 2009 | Article

Topics: Alzheimer’s disease Cognitive assessment ADNI Cognitive outcomes Biostatistics Clinical trials

P1-269: The ADAS-cog’s performance as a measure-lessons from the ADNI study: Part 1-evaluation using traditional psychometric methods

Posner, Holly, Cano, Stefan, Aisen, Paul, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 5(4S_Part_9) | 2009 | Article

Topics: Alzheimer’s disease Cognitive assessment Cognitive outcomes ADNI Clinical trials Neuropsychology Longitudinal

O4-04-07: The ADAS-cog’s performance as a measure—lessons from the ADNI study: Part 2-evaluation using modern psychometric methods

Cano, Stefan, Posner, Holly, Aisen, Paul, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 5(4S_Part_5) | 2009 | Article

Topics: Alzheimer’s disease Cognitive assessment Cognitive outcomes ADNI Clinical trials Neuropsychology

2008

Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer’s disease: a randomised, double-blind, placebo-controlled study

Doody, Rachelle S, Gavrilova, Svetlana I, Sano, Mary, …, Thomas, Ronald G, et al. | The Lancet | vol. 372(9634) | 2008 | Article

Topics: Alzheimer’s disease Randomized controlled trial Placebo-controlled Clinical trials Drug development Cognitive outcomes Functional outcomes ADCS

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High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial

Aisen, Paul S, Schneider, Lon S, Sano, Mary, …, Thomas, Ronald G, et al. | Jama | vol. 300(15) | 2008 | Article

Topics: Alzheimer’s disease Randomized controlled trial Placebo-controlled Clinical trials Cognitive outcomes ADCS

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Efficacy of site-independent telemedicine in the STRokE DOC trial: a randomised, blinded, prospective study

Meyer, Brett C, Raman, Rema, Hemmen, Thomas, …, Thomas, Ronald G, et al. | The Lancet Neurology | vol. 7(9) | 2008 | Article

Topics: Randomized controlled trial Clinical trials Placebo-controlled Biostatistics Medical research

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A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium

Khachaturian, Zaven S, Petersen, Ronald C, Gauthier, Serge, …, Thomas, Ronald G, et al. | Alzheimer’s & dementia: the journal of the Alzheimer’s Association | vol. 4(3) | 2008 | Article

Topics: Alzheimer’s disease Dementia Prevention trial Medical research Public health Biomarkers Epidemiology

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Ametropia, preschoolers’ cognitive abilities, and effects of spectacle correction

Roch-Levecq, Anne-Catherine, Brody, Barbara L, Thomas, Ronald G, Brown, Stuart I | Archives of ophthalmology | vol. 126(2) | 2008 | Article

Topics: Cognitive assessment Neuropsychology Medical research Cognitive outcomes Ophthalmology

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P4-343: Omega 3 fatty acids and Alzheimer’s disease: Trial design and baseline study population characteristics in a clinical trial of docosahexanoic acid for Alzheimer’s disease

Quinn, Joseph F, Raman, Rema, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 4 | 2008 | Article

Topics: Alzheimer’s disease Clinical trials Randomized controlled trial Placebo-controlled Cognitive outcomes Biomarkers ADCS

O2-04–06: Randomized clinical trial of antioxidant treatment in Alzheimer’s disease with CSF biomarker measures

Galasko, Douglas, Peskind, Elaine, Clark, Christopher M, …, Thomas, Ronald G | Alzheimer’s & Dementia | vol. 4 | 2008 | Article

Topics: Alzheimer’s disease Randomized controlled trial Placebo-controlled Csf Biomarkers Biomarkers ADCS Clinical trials

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P4-337: Dimebon improves cognition, function, and behavior in mild and moderate Alzheimer’s disease: Results by severity of a one-year, double-blind, placebo-controlled study

Doody, Rachelle S, Gavrilova, Svetlana, Thomas, Ronald G, et al. | Alzheimer’’s and Dementia | vol. 4(4) | 2008 | Article

Topics: Alzheimer’s disease Randomized controlled trial Placebo-controlled Clinical trials Cognitive outcomes Functional outcomes

P4-387: Adding delayed recall to the Alzheimer’s disease assessment scale-cognitive subscale (ADAS-cog): Sensitivity in a clinical trial for Alzheimer’s disease and mild cognitive impairment

Raman, Rema, Emond, Jennifer, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 4 | 2008 | Article

Topics: Alzheimer’s disease Mild cognitive impairment Cognitive outcomes Cognitive assessment Clinical trials ADCS Biostatistics

Statistical treatment of withdrawal in trials of anti-dementia drugs–Authors’ reply

Doody, Rachelle, Seely, Lynn, Thomas, Ronald G, Sano, Mary, Aisen, Paul | The Lancet | vol. 372(9647) | 2008 | Article

Topics: Alzheimer’s disease Clinical trials Missing data Biostatistics ADCS Longitudinal Randomized controlled trial

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Alzheimer Disease Cooperative Study. High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial

Aisen, PS, Schneider, LS, Sano, M, …, Thomas, Ronald G, et al. | Jama | vol. 300(15) | 2008 | Article

Topics: Alzheimer’s disease Randomized controlled trial ADCS Clinical trials Cognitive outcomes Placebo-controlled Drug development

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Brody BL

Roch-Levecq AC | Thomas | vol. and effects of spectacle correction. Arch Ophthalmol. Feb;126(2) | 2008 | Article

Topics: Aging Medical research Cognitive outcomes Clinical trials Functional outcomes Epidemiology

2007

Potential outcome measures and trial design issues for multiple system atrophy

May, Susanne, Gilman, Sid, Sowell, B Brooke, …, Thomas, Ronald G, et al. | Movement disorders | vol. 22(16) | 2007 | Article

Topics: Neurodegeneration Clinical trials Cognitive outcomes Biostatistics Sample size Medical research

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S3–02–01: ADCS homocysteine trial

Aisen, Paul S, Jin, Shelia, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 3(3S_Part_3) | 2007 | Article

Topics: Alzheimer’s disease ADCS Clinical trials Cognitive outcomes Biostatistics

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Population Dynamics of Meloidogyne incognita and RotylenchulusTenchulus reniformis Alone and in Combination, and Their Effects on Sweet Potato1

Thomas, Ronald G, CLARK, CHRISTOPHER A | 2007 | Article

Topics: Medical research Epidemiology Biostatistics Longitudinal Nematology

Results of a one-year randomized, placebo-controlled trial of Dimebon for the treatment of mild to moderate Alzheimer’s Disease

Doody, RS, Gavrilova, S, Sano, M, …, Thomas, Ronald G, et al. | Alzheimer’s and Dementia | vol. 3 | 2007 | Article

Topics: Alzheimer’s disease Randomized controlled trial Placebo-controlled Clinical trials Cognitive outcomes ADCS

2006

ADCS Prevention Instrument Project: pharmacoeconomics: assessing health-related resource use among healthy elderly

Sano, Mary, Zhu, Carolyn W, Whitehouse, Peter J, …, Thomas, Ronald G, et al. | Alzheimer disease and associated disorders | vol. 20(4 Suppl 3) | 2006 | Article

Topics: Alzheimer’s disease Mild cognitive impairment Prevention trial Clinical trials ADCS Aging Healthcare analytics

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Thomas

Raman R | Ronald G.. “A Centralized Serious Adverse Event Reporting and Coding System for Multi-Center Clinical Trials – An Academic Research Organization Experience.” Clinical Trials (3): 194-195 | 2006 | Article

Topics: Clinical trials Data safety monitoring Medical research Biostatistics ADCS

2005

Vitamin E and donepezil for the treatment of mild cognitive impairment

Petersen, Ronald C, Thomas, Ronald G, et al. | New England Journal of Medicine | vol. 352(23) | 2005 | Article

Topics: Mild cognitive impairment Randomized controlled trial Placebo-controlled ADCS ADNI Clinical trials Cognitive outcomes Drug development

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Detailed assessment of activities of daily living in moderate to severe Alzheimer’s disease

Galasko, D, Schmitt, F, Thomas, Ronald G, Jin, S, Bennett, D, Ferris, S | Journal of the International Neuropsychological Society: JINS | vol. 11(4) | 2005 | Article

Topics: Alzheimer’s disease Dementia Functional outcomes Cognitive assessment Clinical trials ADCS Neuropsychology

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Self-management of age-related macular degeneration at the 6-month follow-up: a randomized controlled trial

Brody, Barbara L, Roch-Levecq, Anne-Catherine, Thomas, Ronald G, Kaplan, Robert M, Brown, Stuart I | Archives of Ophthalmology | vol. 123(1) | 2005 | Article

Topics: Randomized controlled trial Clinical trials Aging Medical research Functional outcomes Public health

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Divalproex sodium in nursing home residents with possible or probable Alzheimer disease complicated by agitation: a randomized, controlled trial

Tariot, Pierre N, Raman, Rema, Jakimovich, Laura, …, Thomas, Ronald G, et al. | The American journal of geriatric psychiatry | vol. 13(11) | 2005 | Article

Topics: Alzheimer’s disease Dementia Randomized controlled trial Placebo-controlled Clinical trials Drug development Cognitive outcomes ADCS

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Analysis of apoptosis protein expression in early-stage colorectal cancer suggests opportunities for new prognostic biomarkers

Krajewska, Maryla, Kim, Hoguen, Kim, Chul, …, Thomas, Ronald G, et al. | Clinical Cancer Research | vol. 11(15) | 2005 | Article

Topics: Cancer Biomarkers Medical research Diagnostic testing Colorectal cancer

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Propranolol for disruptive behaviors in nursing home residents with probable or possible Alzheimer disease: a placebo-controlled study

Peskind, Elaine R, Tsuang, Debby W, Bonner, Lauren T, …, Thomas, Ronald G, et al. | Alzheimer Disease & Associated Disorders | vol. 19(1) | 2005 | Article

Topics: Alzheimer’s disease Dementia Randomized controlled trial Placebo-controlled Clinical trials Drug development ADCS

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Cognitive Outcomes of Corrective Lenses on Low Income Preschoolers With Hyperopia/Astimgatism: A Longitudinal Pilot Study

Roch–Levecq, A–C, Brody, B, Thomas, Ronald G, Brown, SI | Investigative Ophthalmology & Visual Science | vol. 46(13) | 2005 | Article

Topics: Cognitive outcomes Longitudinal Medical research Cognitive assessment Ophthalmology

Petersen, Ronald C, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 1 | 2005 | Article

Topics: Mild cognitive impairment Clinical trials Alzheimer’s disease ADCS Cognitive assessment Randomized controlled trial

Thal, Leon J, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 1 | 2005 | Article

Topics: Mild cognitive impairment Alzheimer’s disease Clinical trials Placebo-controlled ADCS Survival Analysis Drug development

2004

Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials

Grundman, Michael, Petersen, Ronald C, Ferris, Steven H, …, Thomas, Ronald G, et al. | Archives of neurology | vol. 61(1) | 2004 | Article

Topics: Mild cognitive impairment Alzheimer’s disease Clinical trials Cognitive assessment Cognitive outcomes ADCS Biostatistics

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A comparison of episodic memory deficits in neuropathologically-confirmed Dementia with Lewy bodies and Alzheimer’s disease

Hamilton, Joanne M, Salmon, David P, Galasko, Douglas, …, Thomas, Ronald G, et al. | Journal of the International Neuropsychological Society: JINS | vol. 10(5) | 2004 | Article

Topics: Alzheimer’s disease Dementia Neuropsychology Cognitive assessment Cognitive outcomes Neuroimaging

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Reliability of monitoring the clinical dementia rating in multicenter clinical trials

Schafer, Kimberly A, Tractenberg, Rochelle E, Sano, Mary, …, Thomas, Ronald G, et al. | Alzheimer disease and associated disorders | vol. 18(4) | 2004 | Article

Topics: Alzheimer’s disease Dementia Multicenter trial Cognitive assessment Clinical trials ADCS Longitudinal

P1-322 A multicenter, randomized, double-blind, placebo-controlled trial of valproate for agitation associated with dementia

Tariot, Pierre N, Thal, Leon, Jakimovich, Laura, Thomas, Ronald G, Raman, Rema | Neurobiology of Aging | 2004 | Article

Topics: Dementia Randomized controlled trial Placebo-controlled Multicenter trial Clinical trials Alzheimer’s disease ADCS

P1-003 ADCS Prevention instrument project: assessment of activities of daily living (ADL)

Galasko, Douglas, Bennett, David, Sano, Mary, Marson, Daniel, Jin, Shelia, Thomas, Ronald G | Neurobiology of Aging | 2004 | Article

Topics: Alzheimer’s disease ADCS Prevention trial Functional outcomes Cognitive assessment Clinical trials

S5-03-02 Prevention trials in Alzheimer’s disease: design issues

Thal, Leon | Neurobiology of Aging | 2004 | Article

Topics: Alzheimer’s disease Prevention trial Clinical trials ADCS Sample size Biostatistics Adaptive Design

Alzheimer’s Disease

Thal, Leon J, Thomas, Ronald G | Textbook of Clinical Trials | 2004 | Book chapter

Topics: Alzheimer’s disease Medical research ADCS Neuropsychology Clinical trials

Prevalence of behavioral disturbance in Alzheimer’s Disease

Tractenberg, Rochelle E, Weiner, Myron, Thomas, Ronald G, Teri, Linda, Whitehouse, Peter J, Thal, Leon J | Research and Practice in Alzheimer’s Disease | vol. 9 | 2004 | Book chapter

Topics: Alzheimer’s disease Cognitive outcomes ADCS Epidemiology Cognitive assessment

2003

Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial

Aisen, Paul S, Schafer, Kimberly A, Grundman, Michael, …, Thomas, Ronald G, et al. | Jama | vol. 289(21) | 2003 | Article

Topics: Alzheimer’s disease Randomized controlled trial Placebo-controlled Clinical trials Cognitive outcomes ADCS

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Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study

Raskind, Murray A, Peskind, Elaine R, Kanter, Evan D, …, Thomas, Ronald G, et al. | American Journal of Psychiatry | vol. 160(2) | 2003 | Article

Topics: PTSD Sleep disorders Military health Randomized controlled trial Placebo-controlled Clinical trials VA Cooperative Studies

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A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer’s disease

Singer, Clifford, Tractenberg, Rochelle E, Kaye, Jeffrey, …, Thomas, Ronald G, et al. | Sleep | vol. 26(7) | 2003 | Article

Topics: Alzheimer’s disease Sleep disorders Multicenter trial Placebo-controlled Clinical trials ADCS Randomized controlled trial

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Idebenone treatment fails to slow cognitive decline in Alzheimer’s disease

Thal, LJ, Grundman, M, Berg, J, …, Thomas, Ronald G | Neurology | vol. 61(11) | 2003 | Article

Topics: Alzheimer’s disease Dementia Randomized controlled trial Placebo-controlled Clinical trials Cognitive outcomes Drug development ADCS

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Estrogen levels do not correlate with improvement in cognition

Thal, Leon J, Thomas, Ronald G, Mulnard, Ruth, Sano, Mary, Grundman, Michael, Schneider, Lon | Archives of Neurology | vol. 60(2) | 2003 | Article

Topics: Alzheimer’s disease Randomized controlled trial Cognitive outcomes Placebo-controlled Clinical trials ADCS

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Hippocampal volume is associated with memory but not nonmemory cognitive performance in patients with mild cognitive impairment

Grundman, Michael, Jack, Clifford R, Petersen, Ronald C, …, Thomas, Ronald G, et al. | Journal of Molecular Neuroscience | vol. 20(3) | 2003 | Article

Topics: Mild cognitive impairment Alzheimer’s disease Neuroimaging Cognitive outcomes Biomarkers ADCS

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A multicenter, randomized, placebo controlled, multiple-dose, safety and pharmacokinetic study of AIT-082 (Neotrofin™) in mild Alzheimer’s disease patients

Grundman, M, Capparelli, E, Kim, HT, …, Thomas, Ronald G, et al. | Life sciences | vol. 73(5) | 2003 | Article

Topics: Alzheimer’s disease Randomized controlled trial Multicenter trial Placebo-controlled Clinical trials Pharmacokinetics Drug development Dose-finding ADCS

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NSAIDs and hypertension

Aisen, Paul S, Schafer, Kimberly, Grundman, Michael, Thomas, Ronald G, Thal, Leon J | Archives of internal medicine | vol. 163(9) | 2003 | Article

Topics: Alzheimer’s disease Clinical trials Cardiovascular disease Drug development ADCS Medical research

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Steroid-induced elevation of glucose in Alzheimer’s disease: relationship to gender, apolipoprotein E genotype and cognition

Aisen, PS, Berg, JD, Craft, S, …, Thomas, Ronald G, et al. | Psychoneuroendocrinology | vol. 28(1) | 2003 | Article

Topics: Alzheimer’s disease Clinical trials Cognitive outcomes Biomarkers ADCS Diabetes

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Jack CR Jr

Grundman M | Petersen RC | vol. Thal LJ; Alzheimer’s Disease Cooperative Study. Hippocampal volume is associated with memory but not nonmemory cognitive performance in patients with mild cognitive impairment. Journal Molecular Neuroscience ; 20(3) | 2003 | Article

Topics: Alzheimer’s disease Mild cognitive impairment ADCS Clinical trials Cognitive outcomes Biomarkers Longitudinal

2002

A randomized trial of the effect of a plant-based dietary pattern on additional breast cancer events and survival:: the Women’s Healthy Eating and Living (WHEL) Study

Pierce, John P, Faerber, Susan, Wright, Fred A, …, Thomas, Ronald G, et al. | Controlled clinical trials | vol. 23(6) | 2002 | Article

Topics: Cancer Randomized controlled trial Clinical trials Longitudinal Public health

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Alzheimer’s disease can be accurately diagnosed in very mildly impaired individuals

Salmon, David P, Thomas, Ronald G, et al. | Neurology | vol. 59(7) | 2002 | Article

Topics: Alzheimer’s disease Mild cognitive impairment Dementia Cognitive assessment Neuropsychology Diagnostic testing ADCS

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Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial

Grundman, Michael, Sencakova, Drahomira, Jack, Clifford R, …, Thomas, Ronald G, et al. | Journal of Molecular Neuroscience | vol. 19(1) | 2002 | Article

Topics: Mild cognitive impairment ADCS Neuroimaging Cognitive outcomes Clinical trials Biomarkers Longitudinal

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Decline in verbal memory during preclinical Alzheimer’s disease: examination of the effect of APOE genotype

Lange, Kelly L, Bondi, Mark W, Salmon, David P, …, Thomas, Ronald G, et al. | Journal of the International Neuropsychological Society: JINS | vol. 8(7) | 2002 | Article

Topics: Alzheimer’s disease Mild cognitive impairment Cognitive outcomes Neuropsychology Cognitive assessment Biomarkers Longitudinal

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Assessing Alzheimer’s disease patients with the Cohen-Mansfield Agitation Inventory: scoring and clinical implications

Weiner, Myron F, Tractenberg, Rochelle E, Jin, Shelia, …, Thomas, Ronald G, et al. | Journal of psychiatric research | vol. 36(1) | 2002 | Article

Topics: Alzheimer’s disease Dementia Cognitive assessment Neuropsychology Cognitive outcomes ADCS

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A phase I study of AIT-082 in healthy elderly volunteers

Grundman, Michael, Farlow, Martin, Peavy, Guerry, …, Thomas, Ronald G, et al. | Journal of Molecular Neuroscience | vol. 18(3) | 2002 | Article

Topics: Alzheimer’s disease Phase 2 Trial Clinical trials Drug development Pharmacokinetics Aging

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Investigating emergent symptomatology as an outcome measure in a behavioral study of Alzheimer’s disease

Tractenberg, Rochelle E, Gamst, Anthony, Thomas, Ronald G, Patterson, Marian, Schneider, Lon S, Thal, Leon J | The Journal of neuropsychiatry and clinical neurosciences | vol. 14(3) | 2002 | Article

Topics: Alzheimer’s disease Cognitive outcomes Functional outcomes ADCS Clinical trials Neuropsychology

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Psychosocial and Functional Parameters in Patients with Age Related Macular Degeneration and Choroidal Neovascularization with and without Photodynamic Therapy

Goldberg, DE, Roch-Levecq, AC, Maclean, KK, …, Thomas, Ronald G, et al. | Investigative Ophthalmology & Visual Science | vol. 43(13) | 2002 | Article

Topics: Medical research Functional outcomes Randomized controlled trial Aging Epidemiology

No long-term effect of behavioral treatment on psychotropic drug use for agitation in Alzheimer’s disease patients

Weiner, Myron F, Tractenberg, Rochelle E, Sano, Mary, …, Thomas, Ronald G, et al. | Journal of geriatric psychiatry and neurology | vol. 15(2) | 2002 | Article

Topics: Alzheimer’s disease Randomized controlled trial Clinical trials ADCS Cognitive outcomes Functional outcomes

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Use of Brain MRI Volumetric Analysis in a Mild Cognitive Impairment Trial to

Grundman, Michael, Sencakova, Drahomira, Jack Jr, Clifford R, …, Thomas, Ronald G, et al. | Drug Discovery and Development for Alzheimer’s Disease, 2000 | 2002 | Article

Topics: Mild cognitive impairment Neuroimaging Clinical trials ADCS Alzheimer’s disease Cognitive outcomes Biomarkers

., Thal LJ

Singer, C., Tractenberg, R., Kaye, J., …, Thomas, Ronald G, et al. | “ADCS clinical trial of melatonin for the sleep disturbance of Alzheimer’s.” American Journal of Geriatric Psychiatry | vol. 10 | 2002 | Article

Topics: Alzheimer’s disease Sleep disorders ADCS Randomized controlled trial Placebo-controlled Clinical trials Biostatistics

2001

Metabolic syndrome and ischemic heart disease in elderly men and women

Lindblad, Ulf, Langer, Robert D, Wingard, Deborah L, Thomas, Ronald G, Barrett-Connor, Elizabeth L | American journal of epidemiology | vol. 153(5) | 2001 | Article

Topics: Cardiovascular disease Diabetes Epidemiology Aging Biostatistics Longitudinal

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Frequency of behavioral symptoms characterizes agitation in Alzheimer’s disease

Tractenberg, Rochelle E, Gamst, Anthony, Weiner, Myron F, …, Thomas, Ronald G, et al. | International journal of geriatric psychiatry | vol. 16(9) | 2001 | Article

Topics: Alzheimer’s disease Dementia Neuropsychology Cognitive assessment Cognitive outcomes ADCS

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Langer RD, Wingard DL, Thomas, Ronald G..

Lindblad U | Barrett -Connor EL. The metabolic syndrome and ischemic heart disease in elderly men and women. American Journal of Epidemiology | vol. 153 | 2001 | Article

Topics: Cardiovascular disease Epidemiology Aging Biostatistics Public health

., Schafer K, Thal LJ

Teri, L., Logsdon, R.G., Peskind, E., …, Thomas, Ronald G, et al. | “Treatment of agitation in Alzheimer’s disease: An investigation of haloperidol, trazodone and behavior management techniques.” In Vellas B, Fitten J(Eds.), Research and Practice in Alzheimer’s Disease and other Dementias. Research and Practice in Alzheimer’s Disease Volume | vol. 5 | 2001 | Article

Topics: Alzheimer’s disease Dementia Randomized controlled trial Clinical trials Cognitive outcomes Functional outcomes Neuropsychology

Treatment of agitation in Alzheimer’s disease: An investigation of haloperidol, trazodone and behavior management techniques

Teri, Linda, Logsdon, Rebecca G, Peskind, Elaine, …, Thomas, Ronald G, et al. | Research and Practice in Alzheimer’s Disease and other Dementias | vol. 5 | 2001 | Book chapter

Topics: Alzheimer’s disease Clinical trials Cognitive outcomes ADCS Randomized controlled trial

2000

Analysis of longitudinal data in an Alzheimer’s disease clinical trial

Thomas, Ronald G, Berg, Julie D, Sano, Mary, Thal, Leon | Statistics in medicine | vol. 19(11-12) | 2000 | Article

Topics: Alzheimer’s disease Longitudinal Clinical trials Biostatistics Mixed models Missing data Cognitive outcomes ADCS

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A randomized controlled trial of prednisone in Alzheimer’s disease

Aisen, Paul S, Davis, KL, Berg, JD, …, Thomas, Ronald G, et al. | Neurology | vol. 54(3) | 2000 | Article

Topics: Alzheimer’s disease ADCS Randomized controlled trial Placebo-controlled Clinical trials Drug development

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Treatment of agitation in AD: a randomized, placebo-controlled clinical trial

Teri, Linda, Logsdon, RG, Peskind, E, …, Thomas, Ronald G, et al. | Neurology | vol. 55(9) | 2000 | Article

Topics: Alzheimer’s disease Randomized controlled trial Placebo-controlled Clinical trials Cognitive outcomes ADCS

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Incidence of and risk factors for hallucinations and delusions in patients with probable AD

Paulsen, Jane S, Salmon, DP, Thal, Leon J, …, Thomas, Ronald G, et al. | Neurology | vol. 54(10) | 2000 | Article

Topics: Alzheimer’s disease Dementia Neuropsychology Cognitive outcomes Epidemiology ADCS

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Comparison of the serial position effect in very mild Alzheimer’s disease, mild Alzheimer’s disease, and amnesia associated with electroconvulsive therapy

Bayley, Peter J, Salmon, David P, Bondi, Mark W, …, Thomas, Ronald G, et al. | Journal of the International Neuropsychological Society | vol. 6(3) | 2000 | Article

Topics: Alzheimer’s disease Dementia Neuropsychology Cognitive assessment Cognitive outcomes

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Quantifying behavioral disturbance in Alzheimer’s disease patients

Weiner, Myron F, Tractenberg, Rochelle, Teri, Linda, …, Thomas, Ronald G, et al. | Journal of Psychiatric Research | vol. 34(2) | 2000 | Article

Topics: Alzheimer’s disease Dementia Cognitive outcomes Neuropsychology Cognitive assessment ADCS

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Prevalence of symptoms on the CERAD behavior rating scale for dementia in normal elderly subjects and Alzheimer’s disease patients

Tractenberg, Rochelle E, Patterson, Marian, Weiner, Myron F, …, Thomas, Ronald G, et al. | The Journal of neuropsychiatry and clinical neurosciences | vol. 12(4) | 2000 | Article

Topics: Alzheimer’s disease Dementia Cognitive outcomes Neuropsychology Epidemiology ADCS

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Qualifying change: a method for defining clinically meaningful outcomes of change score computation

Tractenberg, Rochelle E, Jin, Shelia, Patterson, Marian, …, Thomas, Ronald G, et al. | Journal of the American Geriatrics Society | vol. 48(11) | 2000 | Article

Topics: Alzheimer’s disease Cognitive outcomes Cognitive assessment Biostatistics Longitudinal Clinical trials

Use of brain MRI volumetric analysis in a mild cognitive impairment trial to delay the diagnosis of Alzheimer’s disease

Grundman, Michael, Sencakova, Drahomira, Jack, CR, Fillit, H, O’Connell, A | Drug discovery and development for Alzheimer’s disease | 2000 | Article

Topics: Mild cognitive impairment Alzheimer’s disease Neuroimaging Clinical trials Prevention trial Biomarkers

Disorder among Veterans with Substance Abuse

Thomas, Ronald G, MICHAEL, J | THE JOURNaL OF NERvOUs AND MEntal Disease | vol. 22(301800) | 2000 | Article

Topics: Military health PTSD VA Cooperative Studies Public health Epidemiology

Multiple Sclerosis: Current Treatment

Sano, M, Ernesto, C, Thomas, Ronald G, et al. | Melmon and Morrelli’s Clinical Pharmacology: Basic Principles in Therapeutics | 2000 | Article

Topics: Neurodegeneration Medical research Drug development Clinical trials Multiple sclerosis

Ronald G.., Berg, J., Sano, M., Thal, L., “Analysis of Longitudinal Data in an Alzheimer’s Disease Clinical Trial

Thomas | ” Statistics in Medicine | vol. 19 | 2000 | Article

Topics: Alzheimer’s disease Clinical trials Biostatistics Longitudinal Mixed models ADCS

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Clinically-Meaningful

Tractenberg, R.E., Jin, S.J., Patterson, M., …, Thomas, Ronald G, et al. | outcomes of change score computation. Journal of American Geriatric Society Nov.; 48(11):1478-82 | 2000 | Article

Topics: Alzheimer’s disease Cognitive outcomes Clinical trials ADCS Biostatistics Longitudinal

Berg JD, Thomas, Ronald G.., Shcneider LS, A.P.S., Mulnard, R., Thal, L.J.

Sano MC | “Incidence and persistence of psychosis in Alzheimer’s Disease.” Neurology | vol. 56 | 2000 | Article

Topics: Alzheimer’s disease Clinical trials ADCS Cognitive outcomes Neuropsychology Longitudinal Biostatistics

, Kim, H

Grundman, M | T., Morris, J.C., Farlow, M., Heidebrink, J., Hake,A., Rubin, E., Ho, G., Capparelli, E., Schultz, A., Schafer, K., Houston, W., Thomas, R, Thal, L.J., “A Multicenter Randomized Placebo-Controlled, Multiple-Dose, Safety and Pharmacokinetic Study of AIT-082 (Neotrofin) in Mild Alzheimer’s Disease Patients.” Society For Neuroscience | vol. 26 | 2000 | Article

Topics: Alzheimer’s disease Mild cognitive impairment ADCS Clinical trials Cognitive outcomes Biostatistics

Cotman CW, Kawas C, Van Dyck CH, Sano M, Doody, R., Koss, E., Pfeiffer, E., Jin, S., Gamst, A., Grundman, M., Thomas, R, Thal, L.J. for the Alzheimer’s Disease Cooperative Study, “Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer’s Disease

Mulnard RA | ” Journal of American Medical Association | vol. 283 | 2000 | Article

Topics: Alzheimer’s disease Randomized controlled trial ADCS Clinical trials Placebo-controlled Drug development Cognitive outcomes Biostatistics

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Biostatistical Issues in Neurodegenerative Disease

Thomas, Ronald G | 2000 | Book chapter

Topics: Neurodegeneration Biostatistics Clinical trials Longitudinal Medical research

1999

Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer’s disease.

Bondi, Mark W, Salmon, David P, Galasko, Douglas, Thomas, Ronald G, Thal, Leon J | Psychology and aging | vol. 14(2) | 1999 | Article

Topics: Alzheimer’s disease Mild cognitive impairment Neuropsychology Cognitive assessment Biomarkers ADNI Epidemiology

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Weight gain in infants breastfed by mothers who take fluoxetine

Chambers, Christina D, Anderson, Philip O, Thomas, Ronald G, et al. | Pediatrics | vol. 104(5) | 1999 | Article

Topics: Medical research Clinical trials Pharmacokinetics Public health Biostatistics

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Age-related macular degeneration: a randomized clinical trial of a self-management intervention

Brody, Barbara L, Williams, Rebecca A, Thomas, Ronald G, Kaplan, Robert M, Chu, Ray M, Brown, Stuart I | Annals of Behavioral Medicine | vol. 21(4) | 1999 | Article

Topics: Randomized controlled trial Clinical trials Aging Medical research Public health Cognitive outcomes

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Nursing home placement is related to dementia progression: experience from a clinical trial

Knopman, David S, Berg, JD, Thomas, Ronald G, et al. | Neurology | vol. 52(4) | 1999 | Article

Topics: Alzheimer’s disease Dementia Clinical trials Functional outcomes Longitudinal ADCS Cognitive outcomes

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A normative study of Nelson’s (1976) modified version of the Wisconsin Card Sorting Test in healthy older adults

Lineweaver, Tara T, Bondi, Mark W, Thomas, Ronald G, Salmon, David P | The Clinical Neuropsychologist | vol. 13(3) | 1999 | Article

Topics: Aging Neuropsychology Cognitive assessment Cognitive outcomes Medical research

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Assessment of agitation in Alzheimer’s disease: the agitated behavior in dementia scale

Logsdon, Rebecca G, Teri, Linda, Weiner, Myron F, …, Thomas, Ronald G, et al. | Journal of the American Geriatrics Society | vol. 47(11) | 1999 | Article

Topics: Alzheimer’s disease Dementia Cognitive assessment Functional outcomes Neuropsychology ADCS

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Mini-mental state examination and Mattis Dementia Rating Scale performance differs in Hispanic and non-Hispanic Alzheimer’s disease patients

Hohl, Ursula, Grundman, Michael, Salmon, David P, Thomas, Ronald G, Thal, Leon J | Journal of the International Neuropsychological Society | vol. 5(4) | 1999 | Article

Topics: Alzheimer’s disease Dementia Cognitive assessment Neuropsychology ADCS

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Neurochemical markers do not correlate with cognitive decline in the Lewy body variant of Alzheimer disease

Sabbagh, Marwan N, Corey-Bloom, Jody, Tiraboschi, Pietro, Thomas, Ronald G, Masliah, Eliezer, Thal, Leon J | Archives of neurology | vol. 56(12) | 1999 | Article

Topics: Alzheimer’s disease Dementia Neurodegeneration Biomarkers Cognitive outcomes Neuropsychology

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Ethnic differences in clinical measures among participants in Alzheimer’s disease clinical trials

Bell, Karen, Sano, Mary, Jin, Shelia, Thomas, Ronald G, Thal, Leon | Neurology | vol. 52(6) | 1999 | Article

Topics: Alzheimer’s disease Clinical trials ADCS Cognitive outcomes Epidemiology Medical research

The Beneficial Effects of Vitamin E and Selegiline in a Controlled Trial in Alzheimer’s Disease Are Independent of the Apolipoprotein E e4 Allele

Galasko, Douglas, Sano, Mary, Berg, Julie, Thomas, Ronald G, Grundman, Michael, Thal, Leon | Neurology | vol. 52(6) | 1999 | Article

Topics: Alzheimer’s disease Randomized controlled trial Placebo-controlled ADCS Drug development Biomarkers Clinical trials

Clinical symptoms of dementia with Lewy bodies: Secondary analyses of the Alzheimer’s disease cooperative study selegiline and vitamin E clinical trial

Olin, JT, Papka, M, Jin, S, Sano, M, Grundman, M, Thomas, Ronald G | European Neuropsychopharmacology | 1999 | Article

Topics: Dementia Alzheimer’s disease Randomized controlled trial Clinical trials ADCS Cognitive outcomes Biostatistics

K., Thomas, R, Morris, J., Mohs, R., Tractenberg, M., Ryan-Jones, R., Croot, K., Coats, M., Grundman, M., Petersen, R., Thal, L., and Members of the Alzheimer’s Disease Cooperative Study, “Standardizing the Administration of Complex Assessment Measures in Multicenter Clinical Trials

Schafer | ” Controlled Clinical Trials | vol. 20 | 1999 | Article

Topics: Alzheimer’s disease Mild cognitive impairment Clinical trials ADCS Cognitive assessment Multicenter trial Biostatistics

1998

High cerebrospinal fluid tau and low amyloid beta42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype

Galasko, D, Chang, L, Motter, R, …, Thomas, Ronald G, et al. | Archives of neurology | vol. 55(7) | 1998 | Article

Topics: Alzheimer’s disease Csf Biomarkers Tau Amyloid Biomarkers Diagnostic testing

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The psychosocial impact of macular degeneration

Williams, Rebecca A, Brody, Barbara L, Thomas, Ronald G, Kaplan, Robert M, Brown, Stuart I | Archives of ophthalmology | vol. 116(4) | 1998 | Article

Topics: Functional outcomes Medical research Clinical trials Epidemiology Ophthalmology

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Utility of psychophysiological measurement in the diagnosis of posttraumatic stress disorder: results from a Department of Veterans Affairs Cooperative Study.

Keane, Terence M, Kolb, Lawrence C, Kaloupek, Danny G, …, Thomas, Ronald G, et al. | Journal of consulting and clinical psychology | vol. 66(6) | 1998 | Article

Topics: PTSD Military health Biomarkers VA Cooperative Studies Neuropsychology Diagnostic testing Cognitive assessment

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The electrocardiographic exercise test in a population with reduced workup bias: diagnostic performance, computerized interpretation, and multivariable prediction

Froelicher, Victor F, Lehmann, Kenneth G, Thomas, Ronald G, et al. | Annals of internal medicine | vol. 128(12_Part_1) | 1998 | Article

Topics: Cardiovascular disease Diagnostic testing Biomarkers Epidemiology Biostatistics

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Design and baseline characteristics of the veterans affairs non-Q-wave infarction strategies in-hospital (VANQWISH) trial

Ferry, David R, O’Rourke, Robert A, Blaustein, Alvin S, …, Thomas, Ronald G, et al. | Journal of the American College of Cardiology | vol. 31(2) | 1998 | Article

Topics: Cardiovascular disease Randomized controlled trial Multicenter trial Clinical trials Vanqwish Placebo-controlled Biomarkers

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Association of CYP2D microsatellite polymorphism with Lewy body variant of Alzheimer’s disease

Tanaka, S, Chen, X, Xia, Y, …, Thomas, Ronald G, et al. | Neurology | vol. 50(6) | 1998 | Article

Topics: Alzheimer’s disease Dementia Neurodegeneration Biomarkers Epidemiology

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Interaction of apolipoprotein E 4 with other genetic and non-genetic risk factors in late onset Alzheimer disease: problems facing the investigator

Katzman, R, Kang, D, Thomas, Ronald G | Neurochemical research | vol. 23(3) | 1998 | Article

Topics: Alzheimer’s disease Epidemiology Biomarkers Aging Medical research Longitudinal

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The relationship between Nursing home placement and measures of change in Alzheimer’s disease

Knopman, David, Sano, Mary, Berg, Julie, Thomas, Ronald G | Neurology | vol. 50(4) | 1998 | Article

Topics: Alzheimer’s disease Functional outcomes Longitudinal Cognitive outcomes ADCS

Use of the world wide web in data dissemination to central review committees

Schafer, Kimberly A, Welty, Greg, Thomas, Ronald G | Controlled Clinical Trials | vol. 19(3) | 1998 | Article

Topics: Clinical trials Multicenter trial Healthcare analytics Medical research Data management

Dynamic measurement scale development for clinical trials in targeted populations

Jin, Shelia, Thomas, Ronald G, Galasko, Douglas, Thal, Leon J | Controlled Clinical Trials | vol. 19(3) | 1998 | Article

Topics: Clinical trials Cognitive outcomes Biostatistics Alzheimer’s disease Mild cognitive impairment Sample size ADCS

Measuring cognitive progression in Alzheimer’s disease

Berg, Julie D, Thomas, Ronald G, Thal, Leon J, Sano, Mary | Controlled Clinical Trials | vol. 19(3) | 1998 | Article

Topics: Alzheimer’s disease Cognitive outcomes Longitudinal Clinical trials ADCS Cognitive assessment

Power calculation for randomized start design

Kean, Yin M, Thomas, Ronald G, Thal, Leon J | Controlled Clinical Trials | vol. 19(3) | 1998 | Article

Topics: Biostatistics Sample size Clinical trials Alzheimer’s disease ADCS Randomized controlled trial

Practice effects on the modified Wisconsin card sorting test in normally aging adults

Lineweaver, TT, Bondi, MW, Thomas, Ronald G | Archives of Clinical Neuropsychology | vol. 13(1) | 1998 | Article

Topics: Aging Cognitive assessment Neuropsychology Cognitive outcomes Medical research

A comparison of the Cohen-Mansfield agitation inventory with the cerad behavioral rating scale for dementia in community-dwelling persons with Alzheimers disease

Weiner, Myron F, Koss, Elisabeth, Patterson, Marian, …, Thomas, Ronald G, et al. | Journal of psychiatric research | vol. 32(6) | 1998 | Article

Topics: Alzheimer’s disease Dementia Cognitive assessment Neuropsychology Medical research Biomarkers

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Agreement on CDR ratings by committee

Tractenberg, Rochelle, Schafer, Kimberly, Thomas, Ronald G, Morris, John C | Controlled Clinical Trials | vol. 19(3) | 1998 | Article

Topics: Alzheimer’s disease ADCS Clinical trials Cognitive assessment Multicenter trial Biostatistics

Outcomes in Patients with Acute Non-Q-Wave Myocardial Infarction Randomly Assigned to an Invasive as Compared with a Conservative Management Strategy

Boden, E.W., O’Rourke, R.A., Crawford, M.H., …, Thomas, Ronald G, et al. | The New England Journal of Medicine | vol. 338 | 1998 | Article

Topics: Cardiovascular disease Randomized controlled trial Clinical trials Medical research Biostatistics Functional outcomes

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The Incidence of Alzheimer’s Disease is Greater than Expected; Analyses Based on the Shanghai Survey

Katzman, R, Yu, E, Liu, W, …, Thomas, Ronald G, et al. | Neurobiology of Aging (S) S | vol. 19 | 1998 | Article

Topics: Alzheimer’s disease Neurodegeneration Epidemiology Medical research Aging

The Diagnosis of Alzheimer’s Disease in Very Mildly Impaired Patients

Salmon, D, Katzman, R, Thomas, Ronald G, Pay, M, Booth, A, Hofstetter, R | Neurobiology of Aging (S) S S | vol. 19 | 1998 | Article

Topics: Alzheimer’s disease Mild cognitive impairment Cognitive assessment Neuropsychology ADCS Diagnostic testing Aging

Cognitive, Functional and Behavioral Outcomes in Clinical Trials Measuring Disease Progression in Alzheimer’s Disease: Selegiline and Vitamin E

Sano, M., J, Berg, J, Thomas, Ronald G, Thal, L.,, the Members of the Alzheimer’s Disease Cooperative Study | Neurobiology of Aging (S) S | vol. 19 | 1998 | Article

Topics: Alzheimer’s disease Clinical trials Randomized controlled trial ADCS Cognitive outcomes Functional outcomes Longitudinal

1997

ApoE genotype influences the CSF level of A \β 42 in Alzheimer’s disease

Seubert, PA, Motter, RN, Schenk, DB, …, Thomas, Ronald G, et al. | Neurology | vol. 48(3) | 1997 | Article

Topics: Alzheimer’s disease Csf Biomarkers Amyloid Biomarkers Medical research

An inventory to assess activities of daily living for clinical trials in Alzheimer’s disease.

Galasko, Douglas, Bennett, David, Sano, Mary, …, Thomas, Ronald G, et al. | Alzheimer disease and associated disorders | 1997 | Article

Topics: Alzheimer’s disease Clinical trials Functional outcomes Cognitive outcomes Cognitive assessment ADCS

Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), and apolipoprotein E receptor, with late-onset Alzheimer’s disease

Kang, DE, Saitoh, T, Chen, X, …, Thomas, Ronald G, et al. | Neurology | vol. 49(1) | 1997 | Article

Topics: Alzheimer’s disease Biomarkers Epidemiology Medical research Aging

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Assessing patterns of agitation in Alzheimer’s disease patients with the Cohen-Mansfield Agitation Inventory. The Alzheimer’s Disease Cooperative Study.

Koss, Elisabeth, Weiner, Myron, Ernesto, Christopher, …, Thomas, Ronald G, et al. | Alzheimer Disease and Associated Disorders | vol. 11 | 1997 | Article

Topics: Alzheimer’s disease Dementia Cognitive assessment Functional outcomes Clinical trials ADCS Neuropsychology

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Effects of apolipoprotein E on dementia and aging in the Shanghai Survey of Dementia

Katzman, R, Zhang, M-Y, Chen, PJ, …, Thomas, Ronald G, et al. | Neurology | vol. 49(3) | 1997 | Article

Topics: Dementia Alzheimer’s disease Aging Epidemiology Biomarkers Longitudinal Neuropsychology

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Defective neurite extension is caused by a mutation in amyloid beta protein precursor found in familial Alzheimer’s disease

Li, Hai Ling, Roch, Jean-Marc, Sundsmo, Mary, …, Thomas, Ronald G, et al. | Journal of neurobiology | vol. 32(5) | 1997 | Article

Topics: Alzheimer’s disease Neurodegeneration Amyloid Medical research Biomarkers

A longitudinal study of behavioral pathology across five levels of dementia severity in Alzheimer’s disease: The CERAD Behavior Rating Scale for Dementia.

Patterson, Marian B, Mack, James L, Mackell, Joan A, …, Thomas, Ronald G, et al. | Alzheimer disease and associated disorders | 1997 | Article

Topics: Alzheimer’s disease Dementia Longitudinal Cognitive outcomes Functional outcomes Neuropsychology

The Spanish Instrument Protocol: Design and implementation of a study to evaluate treatment efficacy instruments for Spanish-speaking patients with Alzheimer’s disease.

Sano, M, Mackell, JA, Ponton, M, …, Thomas, Ronald G, et al. | Alzheimer disease and associated disorders | 1997 | Article

Topics: Alzheimer’s disease Clinical trials Cognitive assessment Multicenter trial Cognitive outcomes ADCS

Tacrine and nursing home placement

Thal, Leon J, Thomas, Ronald G, Sano, Mary | Neurology | vol. 49(3) | 1997 | Article

Topics: Alzheimer’s disease Clinical trials Functional outcomes ADCS Cognitive outcomes

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P23 use of the world wide web for clinical monitoring in multicenter clinical trials

Schafer, Kimberly, Thomas, Ronald G, Welty, Greg, Berry, Angela Lambert, Schittini, Mario | Controlled Clinical Trials | vol. 3(18) | 1997 | Article

Topics: Clinical trials Multicenter trial Medical research Healthcare analytics Data management

Estrogen, apolipoprotein E, and dementia

Barrett-Connor, Elizabeth, Thomas, Ronald G | Journal of women’s health | vol. 6(6) | 1997 | Article

Topics: Dementia Alzheimer’s disease Epidemiology Aging Medical research

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A Multicenter Evaluation of New Treatment Efficacy

Whitehouse, Peter J, Schmitt, HFrederick A, Sano, Mary, Thomas, Ronald G | Alzheimer Disease and Associated Disorders | vol. 11(2) | 1997 | Article

Topics: Alzheimer’s disease Multicenter trial Clinical trials Randomized controlled trial ADCS Cognitive outcomes

Alpha-tocopherol and Alzheimer’s disease-reply

Sano, M, Thomas, Ronald G, Thal, LJ | New England Journal of Medicine | vol. 337(8) | 1997 | Article

Topics: Alzheimer’s disease Clinical trials ADCS Randomized controlled trial Cognitive outcomes

Validity and reliability of the Alzheimer’s Disease Cooperative Study-Clinical global impression of change (ADCS-CGIC)

Schneider, Lon S, Olin, Jason T, Doody, Rachelle S, …, Thomas, Ronald G | Alzheimer Disease | 1997 | Book chapter

Topics: Alzheimer’s disease ADCS Cognitive assessment Cognitive outcomes Medical research

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the Alzheimer’s Disease Cooperative Study. An inventory to assess activities of daily living for clinical trials in Alzheimer’s disease

Galasko, D, Bennett, D, Sano, M, …, Thomas, Ronald G, et al. | Alzheimer Dis Assoc Disord | vol. 11(Suppl 2) | 1997 | Article

Topics: Alzheimer’s disease Clinical trials ADCS Functional outcomes Cognitive outcomes Cognitive assessment Randomized controlled trial

the Alzheimer’s Disease Cooperative Study. Validity and reliability of the Alzheimer’s disease cooperative study-clinical global impression of change

Schneider, LS, Olin, JT, Doody, RS, …, Thomas, Ronald G, et al. | Alzheimer Dis Assoc Disord | vol. 11(suppl 2) | 1997 | Article

Topics: Alzheimer’s disease Clinical trials ADCS Cognitive outcomes Cognitive assessment Biostatistics Randomized controlled trial

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A Multicenter Evaluation of New Treatment Efficacy Instruments for Alzheimer’s Disease Clinical Trials: Overview and General Results

Ferris, S.H, Mackell, J.A, Mohs, R, …, Thomas, Ronald G, et al. | Alzheimer’s Disease and Associated Disorders (Supp.) S S | vol. 11 | 1997 | Article

Topics: Alzheimer’s disease Neurodegeneration Multicenter trial ADCS Clinical trials Cognitive outcomes Biostatistics

Estrogen, Apolipoprotein E, and Dementia [Letter to the Editor],

Barrett-Connor, E., Thomas, Ronald G | Journal of Women’s Health | vol. 6(6) | 1997 | Article

Topics: Dementia Alzheimer’s disease Epidemiology Biomarkers Aging

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Alpha-Tocopherol and Alzheimer’s Disease [Letter to the Editor],

Sano, M., Thomas, Ronald G, Thal, L.J. | New England Journal of Medicine | vol. 337(38) | 1997 | Article

Topics: Alzheimer’s disease Randomized controlled trial ADCS Clinical trials Drug development

Tacrine and Nursing Home Placement [Letter to the Editor],

Thal, L.J., Thomas, Ronald G, Sano, M. | Neurology | vol. 49(3) | 1997 | Article

Topics: Alzheimer’s disease Dementia Clinical trials Cognitive outcomes Medical research

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Power Comparisons Among Different Number of Categories Under Ordered Polytomous Logistic Regression Model

Jeong, J.H, Klauber, M.R, Thomas, Ronald G, Grundman, M, Thal, L.J | Controlled Clinical Trials (Supp. ) S | vol. 18 | 1997 | Article

Topics: Alzheimer’s disease Biostatistics Sample size Clinical trials ADCS Cognitive outcomes Longitudinal

Effects of Selegiline and -tocopherol on Cognitive and Functional Outcome Measures in Moderately Impaired Patients with Alzheimer’s Disease

Sano, M, Ernesto, C, Thomas, Ronald G, et al. | Neurology | vol. 48 | 1997 | Article

Topics: Alzheimer’s disease Clinical trials Randomized controlled trial ADCS Cognitive outcomes Functional outcomes Drug development

Application of Design’s Functions to Build Multivariate Models for Predicting Coronary Artery Disease

Edson, R.G., Lavori, P.W., Froelicker, V.F., Lehmann, K.G., Thomas, Ronald G | Controlled Clinical Trials (Supp.) S | vol. 18 | 1997 | Article

Topics: Cardiovascular disease VA Cooperative Studies Biostatistics Machine learning Clinical trials Diagnostic testing Mixed models

Neurologists’ Interrater Agreement for Parkinsonism in Dementia When Using the UPDRS

Ellis, R.J, Thomas, Ronald G, Galasko, D, Thal, L.J | Journal of Neuropsychiatry and Clinical Neurosciences | vol. 9 | 1997 | Article

Topics: Dementia Alzheimer’s disease Neuropsychology Cognitive assessment ADCS Functional outcomes

Performance of Three Clock Scoring Systems Across Different Ranges of Dementia Severity

DJ, Connor, Bauer, J.A, Salmon, D.P, Thomas, Ronald G, Thal, L.J, N, Butters | Journal of the International Neuropsychological Society () | vol. 3 | 1997 | Article

Topics: Dementia Alzheimer’s disease Neuropsychology Cognitive assessment ADCS Cognitive outcomes

CSF Levels of A432 and Tau as Aids to Diagnosing Alzheimer’s Disease

Galasko, D, Seubert, P, Motter, R, …, Thomas, Ronald G, et al. | American Academy of Neurology | vol. 48 | 1997 | Article

Topics: Alzheimer’s disease Csf Biomarkers Amyloid Tau Biomarkers ADCS Diagnostic testing

A Controlled Trial of Selegeline, Alpha-Tocopherol, or Both as Treatment for Alzheimer’s Disease

Sano, M., Ernesto, C.E, Thomas, Ronald G, et al. | The New England Journal of Medicine | vol. 336(17) | 1997 | Article

Topics: Alzheimer’s disease Randomized controlled trial Placebo-controlled ADCS Clinical trials Drug development Cognitive outcomes Biostatistics

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1996

Apolipoprotein-epsilon4 and head trauma: Synergistic or additive risks?

Katzman, R, Galasko, DR, Saitoh, T, …, Thomas, Ronald G | Neurology | vol. 46(3) | 1996 | Article

Topics: Alzheimer’s disease Traumatic brain injury Neurodegeneration Biomarkers Epidemiology

Rationale and design of a multicenter study of selegiline and alpha-tocopherol in the treatment of Alzheimer disease using novel clinical outcomes. Alzheimer’s Disease Cooperative Study.

Sano, Mary, Ernesto, Christopher, Klauber, Melville R, …, Thomas, Ronald G, et al. | Alzheimer disease and associated disorders | vol. 10(3) | 1996 | Article

Topics: Alzheimer’s disease Randomized controlled trial Multicenter trial Placebo-controlled Clinical trials ADCS Drug development Sample size

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Substance-dependent inpatients who accept smoking treatment

Seidner, Andrea L, Burling, Thomas A, Gaither, David E, Thomas, Ronald G | Journal of Substance Abuse | vol. 8(1) | 1996 | Article

Topics: Medical research Randomized controlled trial Clinical trials Public health Smoking cessation

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ApoE and CYP2D6 polymorphism with and without parkinsonism-dementia complex in the people of Chamorro, Guam

Chen, X, Xia, Y, Gresham, LS, …, Thomas, Ronald G, et al. | Neurology | vol. 47(3) | 1996 | Article

Topics: Alzheimer’s disease Dementia Neurodegeneration Epidemiology Biomarkers Medical research

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Familial melanoma and pancreatic cancer

Wright, Fred A, Thomas, Ronald G | The New England journal of medicine | vol. 334(7) | 1996 | Article

Topics: Cancer Epidemiology Medical research Biostatistics Genetics

A32 computer-aided clinical monitoring: Results of a controlled experiment

Thomas, Ronald G, et al. | Controlled Clinical Trials | vol. 2(17) | 1996 | Article

Topics: Clinical trials Multicenter trial Healthcare analytics Medical research ADCS

P63 Informed consent issues when including genetic testing in clinical trials

Schafer, Kimberly, Thomas, Ronald G, et al. | Controlled Clinical Trials | vol. 2(17) | 1996 | Article

Topics: Alzheimer’s disease Clinical trials ADCS Medical research Biomarkers

A34 Clinical monitoring of rating scales in multicenter clinical trials

Schafer, Kimberly, Ernesto, Christopher, Sano, Mary, Mackell, Joan, Thomas, Ronald G, Morris, John C | Controlled Clinical Trials | vol. 2(17) | 1996 | Article

Topics: Alzheimer’s disease Multicenter trial Clinical trials Cognitive assessment Biostatistics ADCS

Genetic Studies in Alzheimer’s Disease with an NACP/a-Synuclein Polymorphism

Xia, Y, Rohan de Silva, H.A, Rosi, B.L, …, Thomas, Ronald G, et al. | Annals of Neurology | vol. 40 | 1996 | Article

Topics: Alzheimer’s disease Neurodegeneration Biomarkers Medical research Epidemiology

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R., Galasko, D., Saitoh, T., Chen, X., Pay, M.M., Booth, A., Thomas, RG., "Apolipoprotein-epsilon4 and Head Trauma: Synergistic or Additive Risks? [Letter to the Editor]

Katzman | " Neurology | vol. 46 | 1996 | Article

Topics: Alzheimer’s disease Traumatic brain injury Neurodegeneration Biomarkers Epidemiology

Rationale and Design of a Multicenter Study of Selegiline and a-Tocopherol in the Treatment of Alzheimer’s Disease Using Novel Clinical Outcomes

Sano, M, Ernesto, C, Klauber, M.R, …, Thomas, Ronald G, et al. | Alzheimer’s Disease and Associated Disorders | vol. 10 | 1996 | Article

Topics: Alzheimer’s disease Neurodegeneration Randomized controlled trial Multicenter trial ADCS Clinical trials Cognitive outcomes Biostatistics

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Informed Consent Issues When Conducting Genetic Testing in Clinical Trials

Schafer, K, Thomas, Ronald G, et al. | Controlled Clinical Trials (Supp ) S | vol. 17 | 1996 | Article

Topics: Alzheimer’s disease Clinical trials Multicenter trial ADCS Biomarkers Medical research

Clinical Monitoring of Rating Scales in Multicenter Clinical Trials

Schafer, K, Ernesto, C, Sano, M, Mackell, J, Thomas, Ronald G, Morris, J.C | Controlled Clinical Trials (Supp ) S | vol. 17 | 1996 | Article

Topics: Alzheimer’s disease Clinical trials Multicenter trial ADCS Cognitive outcomes Biostatistics Medical research

Computer-Aided Clinical Monitoring: Results of a Controlled Experiment

Thomas, Ronald G, et al. | Controlled Clinical Trials (Supp ) S | vol. 17 | 1996 | Article

Topics: Clinical trials Multicenter trial ADCS Alzheimer’s disease Biostatistics Medical research Cognitive outcomes

Correlation of CognitiveStatus with -tocopherol Levels in Patients with Alzheimer’s Disease

Grundman, M, Sano, M, Thomas, Ronald G, Ernesto, C, Galasko, D, Thal, L.J | Society of Neuroscience ( ) | vol. 22 | 1996 | Article

Topics: Alzheimer’s disease Cognitive outcomes ADCS Clinical trials Biomarkers Neuropsychology

1995

Prospective study of hospitalization for asthma: a preliminary risk factor model

Li, Dominic, German, Donald, Lulla, Sulochina, Thomas, Ronald G, Wilson, Sandra R | American journal of respiratory and critical care medicine | vol. 151(3_pt_1) | 1995 | Article

Topics: Epidemiology Biostatistics Longitudinal Medical research Public health

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1994

Application of neural networks to the classification of giant cell arteritis

Astion, Michael L, Wener, Mark H, Thomas, Ronald G, Hunder, Gene G, Bloch, Daniel A | Arthritis & Rheumatism: Official Journal of the American College of Rheumatology | vol. 37(5) | 1994 | Article

Topics: Machine learning Diagnostic testing Medical research Biostatistics Rheumatology

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Drug and alcohol abuse inpatients’ attitudes about smoking cessation

Irving, Lori M, Seidner, Andrea L, Burling, Thomas A, Thomas, Ronald G, Brenner, Gail F | Journal of Substance Abuse | vol. 6(3) | 1994 | Article

Topics: Medical research Public health Epidemiology Smoking cessation Substance abuse

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A Randomized Trial Comparing Coronary Angioplasty with Coronary Bypass Surgery

King, S.B., Lembo, N.J., Weintraub, W.S., …, Thomas, Ronald G | New England Journal of Medicine | vol. 331 | 1994 | Article

Topics: Cardiovascular disease Randomized controlled trial Clinical trials Medical research Biostatistics

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L., Seidner, A.L., Burling, T.A., Thomas, RG., Brenner, G.F., "Drug and Alcohol Abuse Inpatients Attitudes About Smoking Cessation

Irving | " Journal of Substance Abuse | vol. 6 | 1994 | Article

Topics: Medical research Public health Clinical trials Cognitive assessment Neuropsychology

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1993

Overtraining in neural networks that interpret clinical data

Astion, ML, Wener, MH, Thomas, Ronald G, Hunder, GG, Bloch, DA | Clinical chemistry | vol. 39(9) | 1993 | Article

Topics: Machine learning Diagnostic testing Medical research Biostatistics Neural networks

Algorithm AS 280: the power function for Fisher’s exact test

Conlon, Michael, Thomas, Ronald G | Journal of the Royal Statistical Society. Series C (Applied Statistics) | vol. 42(1) | 1993 | Article

Topics: Biostatistics Exact inference Sample size Clinical trials Hypothesis testing

A controlled trial of two forms of self-management education for adults with asthma

Wilson, Sandra R, Scamagas, Peter, German, Donald F, …, Thomas, Ronald G, et al. | The American journal of medicine | vol. 94(6) | 1993 | Article

Topics: Randomized controlled trial Clinical trials Public health Medical research Respiratory disease

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Prediction of cardiovascular death in men undergoing noninvasive evaluation for coronary artery disease

Morrow, Kiernan, Morris, Charles K, Froelicher, Victor F, …, Thomas, Ronald G, et al. | Annals of Internal Medicine | vol. 118(9) | 1993 | Article

Topics: Cardiovascular disease Survival Analysis Biostatistics Epidemiology Diagnostic testing

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Trimethoprim-sulfamethoxazole prophylaxis in granulocytopenic patients with acute leukemia: evaluation of serum antibiotic levels in a randomized, double-blind, placebo-controlled Department of Veterans Affairs Cooperative Study

Ward, TT, Thomas, Ronald G, et al. | Clinical infectious diseases | vol. 17(3) | 1993 | Article

Topics: Randomized controlled trial Placebo-controlled Clinical trials Medical research VA Cooperative Studies

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The Power Function for Fisher’s Exact Test

Conlon, M, Thomas, Ronald G | Applied Statistics | vol. 42 | 1993 | Article

Topics: Biostatistics Exact inference Conditional Power Sample size Clinical trials

1992

Sample size determination based on Fisher’s exact test for use in 2 x 2 comparative trials with low event rates

Thomas, Ronald G, Conlon, Michael | Controlled clinical trials | vol. 13(2) | 1992 | Article

Topics: Biostatistics Exact inference Sample size Clinical trials Randomized controlled trial

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An algorithm for the rapid evaluation of the power function for Fisher’s Exact Test

Thomas, Ronald G, Conlon, Michael | Journal of statistical computation and simulation | vol. 44(1-2) | 1992 | Article

Topics: Biostatistics Exact inference Sample size Simulation Clinical trials

Concave hymenal variations in suspected child sexual abuse victims

Kerns, David L, Ritter, Mary L, Thomas, Ronald G | Pediatrics | vol. 90(2) | 1992 | Article

Topics: Medical research Epidemiology Public health Forensic medicine Pediatrics

Risk Stratification of Cardiovascular Mortality in Patients with Stable Coronary Artery Disease

Brown, M, Thomas, Ronald G, et al. | Circulation (Supp I) | vol. 86 | 1992 | Article

Topics: Cardiovascular disease Medical research Biostatistics Survival Analysis Epidemiology Clinical trials

1991

An analysis of methods of communication in clinical trials

Sheridan, Lenore, Thomas, Ronald G | Controlled Clinical Trials | vol. 12(5) | 1991 | Article

Topics: Clinical trials Medical research Biostatistics Data safety monitoring Trial management

Reliability and Validity of the Florida Sexual History Questionnaire

Geisser, M.E, Jefferson, T.W, Spevak, M, Boaz, T, Thomas, Ronald G, Murray, F.T | Journal of Clinical Psychology | vol. 47 | 1991 | Article

Topics: Diabetes Medical research Biostatistics Cognitive assessment Epidemiology

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1990

A new confidence interval for the difference of two binomial proportions

Conlon, Michael, Thomas, Ronald G | Computational Statistics & Data Analysis | vol. 9(2) | 1990 | Article

Topics: Biostatistics Exact inference Clinical trials Medical research Hypothesis testing

˙ P-08 An analysis of data collection mechanisms

Tyrell, Doris, Cline, Dorothy R, Thomas, Ronald G | Controlled Clinical Trials | vol. 11(4) | 1990 | Article

Topics: Clinical trials Medical research Healthcare analytics Biostatistics Trial management

Data monitoring through stochastic curtailing when the outcome proportions are small: An exact approach

Thomas, Ronald G | Controlled Clinical Trials | vol. 11(4) | 1990 | Article

Topics: Biostatistics Clinical trials Exact inference Conditional Power Data safety monitoring Sample size

Conditional Power Calculations Through Computer Simulation as an Aid to Data Monitoring,

Lee, K.K., Thomas, Ronald G | Controlled Clinical Trials | vol. 11(4) | 1990 | Article

Topics: Biostatistics Conditional Power Simulation Clinical trials Data safety monitoring Sample size

An Analysis of Data Collection Mechanisms

Tyrell, D.E, Thomas, Ronald G, Cline, D.R | Controlled Clinical Trials | vol. 11 | 1990 | Article

Topics: Clinical trials Biostatistics Medical research Healthcare analytics Data management

1989

Risk factors, time course and treatment effect for restenosis after successful percutaneous transluminal coronary angioplasty of chronic total occlusion

Ellis, Stephen G, Shaw, Richard E, Gershony, Gary, …, Thomas, Ronald G, et al. | The American journal of cardiology | vol. 63(13) | 1989 | Article

Topics: Cardiovascular disease Epidemiology Biostatistics Longitudinal Medical research

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Effect of zinc supplementation on the development of cardiovascular disease in the elderly

Hale, William E, May, Franklin E, Thomas, Ronald G, Moore, Mary T, Stewart, Ronald B | Journal of Nutrition for the Elderly | vol. 8(2) | 1989 | Article

Topics: Cardiovascular disease Aging Randomized controlled trial Medical research Epidemiology

Exact sample size calculations for 2x2 comparative trials when the outcome proportions are small

Thomas, Ronald G | Controlled Clinical Trials | vol. 10(3) | 1989 | Article

Topics: Biostatistics Exact inference Sample size Clinical trials Hypothesis testing

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Predicting Arterial Oxygen Tension Maximum Expiratory Flow Volume Curves in Cystic Fibrosis

Stecenko, A.A, Postotnik, L, Thomas, Ronald G | Pediatric Pulmonology | vol. 6 | 1989 | Article

Topics: Medical research Biostatistics Biomarkers Epidemiology Respiratory disease

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Regional Cerebral Blood Flow for Singers and Non-Singers While Speaking, Singing, and Humming a Note Passage

Formby, C, Thomas, Ronald G, Halsey, J.H | Brain and Language | vol. 36 | 1989 | Article

Topics: Neuroimaging Medical research Neuropsychology Cognitive assessment Neuroscience

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Alterations in the Pulsatile Properties of Luteinizing Hormone in Diabetic Men with Organic Impotence,

Murray, F.T., Rountree, J., Sciadini, M., Wyss, H.U., Thomas, Ronald G | Journal of Andrology | vol. 10 | 1989 | Article

Topics: Diabetes Medical research Biomarkers Epidemiology Longitudinal

1988

Angiographic and clinical predictors of acute closure after native vessel coronary angioplasty.

Ellis, SG, Roubin, GS, King 3rd, SB, …, Thomas, Ronald G, et al. | Circulation | vol. 77(2) | 1988 | Article

Topics: Cardiovascular disease Medical research Randomized controlled trial Biomarkers Epidemiology

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Influence of balloon size on initial success, acute complications, and restenosis after percutaneous transluminal coronary angioplasty. A prospective randomized study.

Roubin, Gary S, Douglas Jr, John S, King 3rd, SB, …, Thomas, Ronald G, et al. | Circulation | vol. 78(3) | 1988 | Article

Topics: Cardiovascular disease Randomized controlled trial Medical research Clinical trials Biostatistics

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Dichloroacetate in the treatment of lactic acidosis

STACPOOLE, PETER W, LORENZ, ANTHEA C, Thomas, Ronald G, HARMAN, ELOISE M | Annals of internal medicine | vol. 108(1) | 1988 | Article

Topics: Medical research Clinical trials Drug development Biostatistics Metabolic disease

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The Pituitary-Testicular Axis at Rest and During Moderate Exercise in Males with Diabetes Mellitus and Normal Sexual Function

Murray, F.T, Cameron, D.F, Vogel, R.B, Thomas, Ronald G, Wyss, H.U, Zauner, C.W | Journal of Andrology | vol. 9 | 1988 | Article

Topics: Diabetes Medical research Biostatistics Exercise intervention Epidemiology

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Antihypertensive Drug Prescribing for an Ambulatory Elderly Population Over an Eight Year Period

Hale, W.E, May, F.E, Chang, Y.F, Thomas, Ronald G, Stewart, R.B | Geriatric Drug Therapy | vol. 3 | 1988 | Article

Topics: Cardiovascular disease Aging Medical research Epidemiology Pharmacokinetics

Restenosis after Coronary Angioplasty for Subacute and Chronic Total Occlusions - Risk Factors Time Course, Treatment Effect

Ellis, S.G, Shaw, R.E, Genshony, G, …, Thomas, Ronald G, et al. | Circulation (Supp II) | vol. 78 | 1988 | Article

Topics: Cardiovascular disease Medical research Clinical trials Biostatistics Epidemiology

The Relationship of Interradicular Width and Alveolar Bone Loss: A Radiometric Study of a Periodontitis Population,

Heins, P.J., Thomas, Ronald G, Newton, J.W. | J | 1988 | Article

Topics: Medical research Biostatistics Epidemiology Dental research Periodontal

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1987

Effects of behavioral self-management on oral hygiene adherence among orthodontic patients

McGlynn, F Dudley, LeCompte, E Joseph, Thomas, Ronald G, Courts, Frank J, Melamed, Barbara G | American Journal of Orthodontics and Dentofacial Orthopedics | vol. 91(1) | 1987 | Article

Topics: Medical research Clinical trials Biostatistics Dental research Behavioral intervention

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Partitioning the Respiratory Effects of Airway Citric Acid and Normal Saline in Lambs

Hutchison, A.H, Caton, D, Thomas, Ronald G, Bucciarelli, R.L | Pediatric Pulmonology | vol. 3 | 1987 | Article

Topics: Medical research Public health Biostatistics Epidemiology Pharmacokinetics

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The Effect of Continuous Phonation on 133-Xenon Inhalation Air Curves (of the Kind Used in Deriving Regional Cerebral Blood Flow)

Formby, C, Thomas, Ronald G, Brown, W.S, Halsey, J.H | Brain and Language | vol. 31 | 1987 | Article

Topics: Medical research Neuropsychology Cognitive assessment Biostatistics Epidemiology

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Hearing Loss Among Stroke Patients

Formby, C, Phillips, D.E, Thomas, Ronald G | Ear and Hearing | vol. 8 | 1987 | Article

Topics: Medical research Epidemiology Biostatistics Cognitive assessment Neuropsychology

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Gonadal Dysfunction in Diabetic Men with Organic Impotence

Murray, F.T, Wyss, H.U, Thomas, Ronald G, Spevack, M, Glaros, A.G | Journal of Clinical Endocrinology and Metabolism | vol. 65 | 1987 | Article

Topics: Diabetes Medical research Biostatistics Epidemiology Endocrinology

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The Impact of Air Filtration on Nosocomial Aspergillis Infections: The Unique Risk of Bone Marrow Transplant Recipients

Sherertz, R.J., Belani, A., Kramer, B.S., …, Thomas, Ronald G, et al. | American Journal of Medicine | vol. 83 | 1987 | Article

Topics: Cancer Medical research Public health Biostatistics Epidemiology

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1986

Alzheimer’s disease: a correlational analysis of the Blessed Information-Memory-Concentration test and the Mini-Mental State Exam

Thal, Leon J, Grundman, Michael, Golden, Robert | Neurology | vol. 36(2) | 1986 | Article

Topics: Alzheimer’s disease Dementia Cognitive assessment Cognitive outcomes Neuropsychology Medical research

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A Test of Instructional Approaches Designed to Influence Food Selection

Maryniuk, M.D., Kauwell, G.P.A., Thomas, Ronald G | The Diabetes Educator | vol. 12 | 1986 | Article

Topics: Diabetes Public health Epidemiology Medical research Cognitive outcomes

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Iodine Retention and Thyroid Dysfunction in Patients on Hemodialysis and Continuous Ambulatory Peritoneal Dialysis

Gardner, D.F, Mars, D.R, Thomas, Ronald G, Bumrungsup, C, Misbin, R.I | American Journal of Kidney Disease | vol. 7 | 1986 | Article

Topics: Medical research Public health Epidemiology Biomarkers Biostatistics

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Hearing Loss Among Aphasics and Other Stroke Patients

Formby, C, Phillips, D.E, Thomas, Ronald G | Journal of the American Speech and Hearing Association | vol. 28 | 1986 | Article

Topics: Neuropsychology Medical research Cognitive assessment Epidemiology Audiology

1985

Effect of Airway Citric Acid and Saline Upon Ventilation and Blood Gases in Newborn Lambs

Hutchison, A.A, Reyes, L, Evans, S.L, Mercer, J.R, Thomas, Ronald G, Bucciarelli, R.L | Pediatric Research | vol. 19 | 1985 | Article

Topics: Medical research Biomarkers Epidemiology Clinical trials Respiratory disease

Testicular Morphometry in Impotent Diabetic Men

Wyss, H.U., Cameron, D.F., Thomas, Ronald G | Diabetes (Supp. ) 05A | vol. 34 | 1985 | Article

Topics: Diabetes Medical research Biomarkers Epidemiology Endocrinology

1984

Changes in shoulder and leg strength in athletes wearing mandibular orthopedic repositioning appliances

Schubert, Mark M, Guttu, Ronald L, Hunter, Letha H, Hall, Richard, Thomas, Ronald G | The Journal of the American Dental Association | vol. 108(3) | 1984 | Article

Topics: Medical research Clinical trials Biostatistics Dental research Sports medicine

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Comparison of Systems for Blood Glucose Monitoring with a Meter: Accu-Check and Glucometer

Silverstein, J.H., Rosenbloom, A.L., Spillar, R.P., Thomas, Ronald G | Diabetes | vol. 33 | 1984 | Article

Topics: Diabetes Diagnostic testing Biomarkers Medical research Endocrinology

The Effects of Prolonged Submaximal Exercise on Testosterone Levels of Untrained Insulin Dependent Diabetic Males,

Murray, F.T., Vogel, R.B., Zauner, C.W., Thomas, Ronald G | Clinical Research | vol. 32 | 1984 | Article

Topics: Diabetes Exercise intervention Medical research Biostatistics Endocrinology

1983

Early prediction of the adult respiratory distress syndrome by a simple scoring method

Pepe, Paul E, Thomas, Ronald G, Stager, Marie Anne, Hudson, Leonard D, Carrico, C James | Annals of emergency medicine | vol. 12(12) | 1983 | Article

Topics: Biomarkers Medical research Diagnostic testing Biostatistics Respiratory disease

Links: Article Add to Zotero

Coronary Artery Surgery Study (CASS): A Randomized Trial of Coronary Artery Bypass Surgery, Survival Data

Associates, CASS: Principal Investigators, Their | Circulation | vol. 63 | 1983 | Article

Topics: Cardiovascular disease Randomized controlled trial Clinical trials Survival Analysis Biostatistics Multicenter trial

Links: Article Add to Zotero

Undated

ADCS Electronic Data Capture (EDC)-Integrated Multi-Modal Image Management for Clinical Trials in Alzheimer’s Disease

Jimenez-Maggiora, Gustavo A, Thomas, Ronald G, Brewer, James, Bruschi, Stefania, Hong, Phuoc, Aisen, Paul S | Article

Topics: ADCS Clinical trials Alzheimer’s disease Medical research Healthcare analytics

University of North Carolina, Chapel Hill, North Carolina (P68)

Mellen, Beverly G, Thomas, Ronald G, Castano, Diego | Article

Topics: Biostatistics Medical research Clinical trials ADCS Cognitive outcomes

Vitamina E y donepezil para el tratamiento del deterioro cognitivo leve

Petersen, Ronald C, Thomas, Ronald G, Grundman, Michael | Article

Topics: Mild cognitive impairment Randomized controlled trial Clinical trials ADCS Cognitive outcomes Drug development

Conference Abstracts

2023

FDG-PET as a Clinical Diagnostic Biomarker for Repetitive Blast Mild Traumatic Brain Injury

Terry, Garth, Pagulayan, Kati, Muzi, Mark, …, Thomas, Ronald G, et al. | NEUROPSYCHOPHARMACOLOGY | vol. 48 | 2023 | Conference paper

Topics: Traumatic brain injury Blast injury Military health Neuroimaging Biomarkers Diagnostic testing

2021

Longitudinal Effects of COVID-19 Related Occupational Stressors on Health Care Workers and First Responders: Implications for Wellbeing, Workplace Retention, Suicidality, and the Relationship of Acute Stress Symptoms to PTSD

Hendrickson, Rebecca, Slevin, Roisin, Hoerster, Katherine, …, Thomas, Ronald G, et al. | NEUROPSYCHOPHARMACOLOGY | vol. 46(SUPPL 1) | 2021 | Conference paper

Topics: PTSD Military health COVID-19 Longitudinal Public health Medical research

Randomized Controlled Trial of Prazosin for Alcohol Use Disorder in Active Duty Service Members

Raskind, Murray, Holmes, Hollie, Williams, Tammy, …, Thomas, Ronald G, et al. | NEUROPSYCHOPHARMACOLOGY | vol. 46(SUPPL 1) | 2021 | Conference paper

Topics: Randomized controlled trial Military health PTSD Clinical trials Placebo-controlled VA Cooperative Studies

2020

PET evidence of preclinical cerebellar amyloid plaque deposition in autosomal dominant Alzheimer’s disease

Ghisays, Valentina, Lopera, Francisco, Goradia, Dhruman D, …, Thomas, Ronald G, et al. | 2020 Alzheimer’s Association International Conference | 2020 | Conference paper

Topics: Alzheimer’s disease API ADAD Amyloid Neuroimaging Biomarkers Mild cognitive impairment

2019

The Alzheimer Prevention Initiative Generation Program: Evaluation of CNP520 in Preclinical Alzheimer’s Disease (P4. 1-005)

Borowsky, Beth, Lopez, Cristina Lopez, Tariot, Pierre, …, Thomas, Ronald G, et al. | Neurology, vol. 92, no. 15_supplement (2019) | 2019 | Abstract

Topics: Alzheimer’s disease Prevention trial Clinical trials Amyloid API ADAD Randomized controlled trial Placebo-controlled Drug development

Links: Article Add to Zotero

Association between cerebral amyloidosis and worse cognitive performance in preclinical autosomal dominant Alzheimer’s disease: Baseline findings from the API Colombia Trial

Quiroz, Y T, Tariot, Pierre N, Sink, K, …, Thomas, Ronald G, et al. | 2019 | Abstract

Topics: API ADAD Alzheimer’s disease Amyloid Cognitive outcomes Neuroimaging

2018

Memantine and Cholinesterase Inhibitor Use in Alzheimer Disease Trials: Potential for Confounding by Indication (P6. 178)

Huisa, Branko, Thomas, Ronald G, Jin, Shelia, Oltersdorf, Tilman, Taylor, Curtis, Feldman, Howard | Neurology, vol. 90, no. 15_supplement (2018) | 2018 | Abstract

Topics: Alzheimer’s disease Clinical trials Randomized controlled trial Drug development Cognitive outcomes ADCS Missing data

Links: Article Add to Zotero

Screening-to-baseline cognitive variability does not predict rate of decline in a clinical trial of mild-to-moderate AD

Jacobs, Diane M, Thomas, Ronald G, Salmon, David P, Huisa, B N, Feldman, H H, Schneider, Lon S | 2018 | Abstract

Topics: Alzheimer’s disease Mild cognitive impairment Cognitive assessment ADCS Longitudinal

A public resource of baseline data from the API Autosomal Dominant Alzheimer’s Disease Colombia Trial

Reiman, Eric M, Sink, K M, Hu, N, …, Thomas, Ronald G, et al. | 2018 | Abstract

Topics: API ADAD Alzheimer’s disease Prevention trial Amyloid Biomarkers

2017

[P4–573]: A PHASE 2 MULTICENTER, RANDOMIZED, PLACEBO-CONTROLLED TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF EDONERPIC (T-817) IN PATIENTS WITH MILD TO MODERATE ALZHEIMER’s DISEASE

Schneider, Lon S, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 13(7S_Part_32) | 2017 | Article

Topics: Alzheimer’s disease Phase 2 Trial Multicenter trial Randomized controlled trial Placebo-controlled Clinical trials ADCS Drug development Cognitive outcomes

Links: Article Add to Zotero

The Alzheimer’s Prevention Initiative (API) Generation Program: Evaluating the Efficacy of the BACE-1 Inhibitor CNP520 in Preclinical Alzheimer’s Disease

Tariot, Pierre, Lopez-Lopez, Cristina, Caputo, Angelika, …, Thomas, Ronald G, et al. | NEUROPSYCHOPHARMACOLOGY | vol. 43 | 2017 | Conference paper

Topics: Alzheimer’s disease Prevention trial Clinical trials API ADAD Amyloid Placebo-controlled Drug development Biomarkers Phase 3 Trial

A Phase 2 Multicenter, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Edonerpic (T-817) in Patients with Mild to Moderate Alzheimer’s Disease

Schneider, Lon S, Thomas, Ronald G, et al. | 2017 | Abstract

Topics: Alzheimer’s disease Phase 2 Trial Multicenter trial ADCS Randomized controlled trial

Rationale for selection of primary endpoints in the Alzheimer Prevention Initiative Generation study in cognitively healthy APOE4 homozygotes

Caputo, A, Racine, A, Paule, I, …, Thomas, Ronald G, et al. | 2017 | Abstract

Topics: API ADAD Alzheimer’s disease Prevention trial Cognitive outcomes Clinical trials Biomarkers

2016

The Alzheimer’s Prevention Initiative Generation Study: A Preclinical Trial in APOE4 Homozygotes

Tariot, Pierre, Langbaum, Jessica, Schneider, Lon, …, Thomas, Ronald G, et al. | NEUROPSYCHOPHARMACOLOGY | vol. 41 | 2016 | Conference paper

Topics: Alzheimer’s disease Prevention trial API ADAD Clinical trials Placebo-controlled Drug development Amyloid Biomarkers Phase 3 Trial

2015

Resveratrol is safe and well-tolerated in individuals with mild-moderate dementia due to Alzheimer’s disease.(S33. 009)

Turner, R, Thomas, Ronald G, et al. | Neurology, vol. 84, no. 14_supplement (2015) | 2015 | Abstract

Topics: Alzheimer’s disease Dementia Clinical trials Placebo-controlled Randomized controlled trial ADCS Drug development

Links: Article Add to Zotero

Safety of Intravenous Immunoglobulin Therapy in Patients with Probable Alzheimer’s Disease: A Randomized, Placebo-Controlled Clinical Study

Gelmont, D, Thomas, Ronald G, Dyck-Jones, JA, Fritsch, S, Aisen, P, Relkin, N | ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY | vol. 115(5) | 2015 | Conference paper

Topics: Alzheimer’s disease Dementia Randomized controlled trial Placebo-controlled Clinical trials ADCS Drug development

2014

Bayesian Longitudinal Modeling on Placebo Data from Alzheimer’s Disease Clinical Studies (P1. 010)

Chen, Yun-Fei, Mohs, Richard, Ding, Ying, Aisen, Paul, Thomas, Ronald G | Neurology, vol. 82, no. 10_supplement (2014) | 2014 | Abstract

Topics: Alzheimer’s disease Clinical trials Bayesian Longitudinal Mixed models Placebo-controlled Biostatistics

Links: Article Add to Zotero

Modeling long-term disease progression with covariates

Donohue, Michael C, Gamst, A, Jack, C, …, Thomas, Ronald G | 2014 | Abstract

Topics: Alzheimer’s disease Longitudinal Mixed models Simulation Missing data

ADCS EDC: Data exchange and processing platform

Jimenez-Maggiora, G A, Thomas, Ronald G, et al. | 2014 | Abstract

Topics: ADCS Healthcare analytics Clinical trials Data management Electronic data capture

2013

P4–157: Adcs electronic data capture: Collaborative development and management of clinical trial databases

Jimenez-Maggiora, Gustavo, Thomas, Ronald G, Bruschi, Stefania, Qiu, Hongmei, Hong, Phuoc, Aisen, Paul | Alzheimer’s & Dementia | vol. 9 | 2013 | Article

Topics: ADCS Clinical trials Alzheimer’s disease Medical research Healthcare analytics

Links: Article Add to Zotero

ADCS electronic data capture: Integrated image management

Jimenez-Maggiora, G, Thomas, Ronald G, Brewer, J, Bruschi, S, Hong, P, Aisen, Paul | 2013 | Abstract

Topics: ADCS Healthcare analytics Neuroimaging Clinical trials Data management

Evaluation of the relationship between TTP488 plasma concentrations and changes in ADAS-cog relative to placebo

Burstein, A, Galasko, Douglas, Aisen, Paul, …, Thomas, Ronald G, et al. | 2013 | Abstract

Topics: Alzheimer’s disease Pharmacokinetics ADCS Plasma biomarkers Drug development

The placebo data analysis in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) clinical trials project: Overview of progress in trial data collection

Thomas, Ronald G, Petersen, Ronald, Siuciak, J, Carrillo, M, Albert, M, Aisen, Paul | 2013 | Abstract

Topics: Alzheimer’s disease Mild cognitive impairment Clinical trials Missing data ADCS

2011

Omega-3 Fatty Acids for Alzheimer’s Disease. What a Pill Can Tell Us about Eating Fish

Quinn, JF, Raman, R, Thomas, Ronald G, et al. | 2011 | Abstract

Topics: Alzheimer’s disease Clinical trials Placebo-controlled ADCS Drug development Biomarkers

2009

The ADAS-cog’s Performance as a Measure Lessons from the ADNI Study: Part 1-Evaluation Using Traditional Psychometric Methods

Pasner, Holly, Cano, Stefan J, Aisen, Paul, …, Thomas, Ronald G, et al. | Neurology | vol. 72(11) | 2009 | Conference paper

Topics: Alzheimer’s disease Cognitive assessment Cognitive outcomes ADNI Clinical trials Neuropsychology

Links: Article Add to Zotero

2007

P-081: The ACDS home assessment instrument: A pilot study

Sano, Mary, Kaye, Jeffrey, Ferris, Steven, …, Thomas, Ronald G, et al. | Alzheimer’s & Dementia | vol. 3(3S_Part_1) | 2007 | Article

Topics: Alzheimer’s disease Cognitive assessment ADCS Cognitive outcomes Biomarkers Medical research

Links: Article Add to Zotero

Dimebon improves cognition, function, and behavior in patients with mild-moderate Alzheimer’s disease: Results of a randomized, double-blind, placebo-controlled study

Doody, Rochelle, Gavrilova, Svetlana, Sano, Mary, …, Thomas, Ronald G, et al. | Neurology | vol. 68(12) | 2007 | Conference paper

Topics: Alzheimer’s disease Randomized controlled trial Placebo-controlled Clinical trials Cognitive outcomes Functional outcomes ADCS

2006

Cognitive changes in the treatment of mild cognitive impairment with donepazil and vitamin E

Petersen, ER, Thomas, Ronald G, Grundman, M, Thal, L | NEUROLOGY | vol. 66(5) | 2006 | Conference paper

Topics: Mild cognitive impairment Cognitive outcomes Clinical trials ADCS Alzheimer’s disease Cognitive assessment

A Centralized Serious Adverse Event Reporting and Coding System for Multi-Center Clinical Trials

Raman, Rema, Thomas, Ronald G | 2006 | Abstract

Topics: Clinical trials ADCS Healthcare analytics Data safety monitoring Adverse events

Validating Remote Data Entry in a Centralized Data Management System

Raman, Rema, Edland, Steven, Simon, L, May, S, Thomas, Ronald G | 2006 | Abstract

Topics: Clinical trials ADCS Healthcare analytics Multicenter trial Data management

2005

Sample size considerations in dementia prevention trials: Data from the Alzheimer’s disease Cooperative Study MCI Trial

Edland, SD, May, S, Emond, JA, …, Thomas, Ronald G | NEUROLOGY | vol. 64(6) | 2005 | Conference paper

Topics: Dementia Alzheimer’s disease Sample size Prevention trial Clinical trials ADCS Biostatistics

Treatment of MCI with cholinesterase inhibitors: current data

Petersen, RC, Thomas, Ronald G, Grundman, M, Thal, L | INTERNATIONAL PSYCHOGERIATRICS | vol. 17 | 2005 | Conference paper

Topics: Mild cognitive impairment Alzheimer’s disease ADCS Drug development Clinical trials Cognitive outcomes

2004

Donepezil and vitamin E as treatments for mild cognitive impairment

Petersen, R, Grundman, M, Thomas, Ronald G, Thal, L | Neurobiology of aging | vol. 25 | 2004 | Conference paper

Topics: Mild cognitive impairment ADCS Randomized controlled trial Placebo-controlled Clinical trials Drug development Cognitive outcomes

Influence of asymptomatic cerebrovascular disease on progression of Alzheimer’s disease

Decarli, C, Jin, S, Sano, Mary, Thomas, Ronald G, Thal, Leon | 2004 | Abstract

Topics: Alzheimer’s disease Neuroimaging Mild cognitive impairment ADCS Longitudinal

2002

Results of a multicenter trial of rofecoxib and naproxen in Alzheimer’s disease

Aisen, P, Schafer, K, Grundman, M, …, Thomas, Ronald G, et al. | Neurobiology of Aging | vol. 23(1) | 2002 | Conference paper

Topics: Alzheimer’s disease Clinical trials Multicenter trial Randomized controlled trial Placebo-controlled ADCS

The ADCS clinical trial of melatonin for the sleep disturbance of alzheimer’s disease: Case report of an unusual sleep/wake cycle and response to melatonin.

Singer, C, Colling, E, Tractenberg, R, …, Thomas, Ronald G, et al. | AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | vol. 10(2) | 2002 | Conference paper

Topics: Alzheimer’s disease Sleep disorders Clinical trials ADCS Sleep Intervention Randomized controlled trial

Clinical correlates of hippocampal atrophy in patients with mild cognitive impairment

Grundman, M, Kim, HT, Schultz, AN, …, Thomas, Ronald G, et al. | NEUROBIOLOGY OF AGING | vol. 23(1) | 2002 | Conference paper

Topics: Mild cognitive impairment Neuroimaging Alzheimer’s disease Cognitive outcomes ADCS Biomarkers

Correlates of weight change in Huntington’s disease

Hamilton, JM, Corey-Bloom, J, Thomas, Ronald G, Peavy, G, Jacobson, MW | NEUROLOGY | vol. 58(7) | 2002 | Conference paper

Topics: Neurodegeneration Cognitive outcomes Neuropsychology Medical research Longitudinal

Indomethacin reduces Helicobacter pylori-induced interleukin-8 (IL-8) production by the gastric epithelial cell line, AGS.

James, MW, Argent, RH, Thomas, Ronald G, Hawkey, C, Atherton, J | GASTROENTEROLOGY | vol. 122(4) | 2002 | Conference paper

Topics: Medical research Biomarkers Drug development Clinical trials Gastroenterology

2001

Incidence and persistence of psychosis in Alzheimer’s disease

Sano, MC, Berg, JD, Thomas, Ronald G, et al. | Neurology | vol. 56(8) | 2001 | Conference paper

Topics: Alzheimer’s disease Neuropsychology Epidemiology Longitudinal ADCS

2000

Predicting nursing home placement with change on cognitive measures in Alzheimer’s disease

Sano, MC, Berg, JD, Knopman, D, Farlow, MR, Thomas, Ronald G | Neurology | vol. 54(7) | 2000 | Conference paper

Topics: Alzheimer’s disease Cognitive outcomes Functional outcomes Longitudinal ADCS Cognitive assessment

Description of behaviors emerging in community-dwelling persons with Alzheimer’s disease over 12 months

Gamst, A, Thomas, Ronald G, Patterson, M, Schneider, L | ANNALS OF NEUROLOGY | vol. 48(3) | 2000 | Conference paper

Topics: Alzheimer’s disease Neuropsychology Longitudinal Cognitive outcomes ADCS

A Multicenter Randomized Placebo-Controlled Safety and Pharmacokinetic Study of AIT-082 (Neotrofin) in Mild Alzheimer’s Disease Patients

Grundman, Michael, Kim, H T, Morris, John C, Farlow, Martin, Thomas, Ronald G, Thal, Leon J | 2000 | Abstract

Topics: Alzheimer’s disease Multicenter trial Pharmacokinetics ADCS Placebo-controlled

1999

Web Based Data Management in a Clinical Trial for the Study of Mild Cognitive Impairment

Campbell, K, Radcliffe, C, Thomas, Ronald G | 1999 | Abstract

Topics: Mild cognitive impairment ADCS Healthcare analytics Clinical trials Data management

Standardizing the Administration of Complex Assessment Measures in Multicenter Clinical Trials

Schafer, Karen, Thomas, Ronald G, Morris, John, Mohs, R, Tractenberg, M | 1999 | Abstract

Topics: Cognitive assessment ADCS Clinical trials Multicenter trial Data management

Evolving From Paper Case Report Forms to Online Data Reporting

Campbell, K, Thomas, Ronald G, Grundman, Michael, Thal, Leon | 1999 | Abstract

Topics: Healthcare analytics ADCS Clinical trials Reproducibility Data management

Online Subject Randomization and Drug Ordering System Using the Web Linked to a Central Data Base

Campbell, K, Radcliffe, C, Thomas, Ronald G, Grundman, Michael, Thal, Leon | 1999 | Abstract

Topics: Healthcare analytics ADCS Randomized controlled trial Clinical trials Data management

1998

Cognitive and functional abilities in severely demented Alzheimer’s patients

Peavy, GM, Salmon, DP, Thomas, Ronald G | CLINICAL NEUROPSYCHOLOGIST | vol. 12(2) | 1998 | Conference paper

Topics: Alzheimer’s disease Cognitive outcomes Functional outcomes Cognitive assessment Neuropsychology

1997

Diagnostic accuracy of dementia with Lewy bodies: A prospective evaluation

Hohl, U, CoreyBloom, J, Hansen, LA, Thomas, Ronald G, Thal, LJ | Neurology | vol. 48(3) | 1997 | Conference paper

Topics: Dementia Alzheimer’s disease Cognitive assessment Diagnostic testing Neuropsychology

Quality of life among elderly adults with macular degeneration

Williams, RA, Brody, BL, Kaplan, RM, Thomas, Ronald G, Brown, SI | INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | vol. 38(4) | 1997 | Conference paper

Topics: Aging Functional outcomes Medical research Epidemiology Cognitive assessment

Use of the World Wide Web for Clinical Monitoring in Multicenter Clinical Trials

Schafer, Karen, Thomas, Ronald G, Welty, G, Berry, A L, Schittini, M | 1997 | Abstract

Topics: Clinical trials ADCS Healthcare analytics Multicenter trial Data management

1996

Rate of dementia of the Alzheimer type (DAT) in subjects with mild cognitive impairment

Grundman, Michael, Petersen, Ronald C, Morris, JC, …, Thomas, Ronald G, et al. | Neurology | vol. 46(2) | 1996 | Conference paper

Topics: Alzheimer’s disease Mild cognitive impairment Dementia Epidemiology Cognitive outcomes Longitudinal ADCS

Evaluation of efficacy measures in clinical trials for Alzheimer’s disease: Does psychometric test performance predict clinically relevant outcomes?

Sano, M, Growdon, J, Thomas, Ronald G, et al. | Neurology | vol. 46(2) | 1996 | Conference paper

Topics: Alzheimer’s disease Cognitive outcomes Clinical trials ADCS Cognitive assessment Biostatistics

Development of a pool of items to assess activities of daily living in clinical trials for Alzheimer’s disease

Galasko, D, Bennett, D, Ernesto, C, Thomas, Ronald G, Sano, M | Neurology | vol. 46(2) | 1996 | Conference paper

Topics: Alzheimer’s disease Clinical trials Functional outcomes Cognitive assessment ADCS

1995

” American Psychiatric Association Meeting

“Assessment of PTSD: The Use of Psychophysiology of PTSD | Miami | 1995 | Conference paper

Topics: PTSD Neuropsychology Cognitive assessment Military health Medical research Biomarkers

1992

PROGRESSION OF FUNCTIONAL DISABILITY IN RHEUMATOID-ARTHRITIS

RAYNAULD, JP, Thomas, Ronald G, BLOCH, DA | ARTHRITIS AND RHEUMATISM | vol. 35(9) | 1992 | Conference paper

Topics: Medical research Longitudinal Functional outcomes Biostatistics Epidemiology

Links: Article Add to Zotero

Psychophysiological Assessment of Posttraumatic Stress Disorder: Results of a Multi-Site Clinical Trial

Keane, T M, Kolb, L C, Thomas, Ronald G | 1992 | Abstract

Topics: PTSD Military health Cognitive assessment Neuropsychology Randomized controlled trial

Classification Tree Stratification for Rheumatoid Arthritis Disability

Reynald, J P, Thomas, Ronald G, Bloch, D A | 1992 | Abstract

Topics: Clinical trials Regression Machine learning Biostatistics Rheumatology

1990

˙ P-59 Conditional power calculations through computer simulation: An aid to data monitoring

Lee, Kelvin K, Thomas, Ronald G | Controlled Clinical Trials | vol. 11(4) | 1990 | Article

Topics: Conditional Power Biostatistics Clinical trials Data safety monitoring Simulation

Links: Article Add to Zotero

A Psychophysiological Study of Chronic PTSD in Vietnam Veterans

Thomas, Ronald G, Keane, T M, Kolb, L C | 1990 | Abstract

Topics: PTSD Military health VA Cooperative Studies Neuropsychology Clinical trials

Interactive Prognostic Model Development Through the Complement use of the Proportional Hazards Model and Recursive Partitioning

James, K E, Thomas, Ronald G, Lee, K K, Watanbe, B | 1990 | Abstract

Topics: Clinical trials Cardiovascular disease Regression Biostatistics Multivariate

Graphical Tools for the Evaluation of the Accuracy of Large Sample Approximations in the Comparison of Two Binomial Proportions

Thomas, Ronald G | 1990 | Abstract

Topics: Biostatistics Simulation Exact inference Data visualization Hypothesis testing

1988

FORMS INVENTORY SYSTEM FOR A COMPLEX CLINICAL-TRIAL

MELLEN, BG, Thomas, Ronald G, CASTANO, D | CONTROLLED CLINICAL TRIALS | vol. 9(3) | 1988 | Conference paper

Topics: Clinical trials Medical research Healthcare analytics Data management Trial management

1987

PROGNOSIS AFTER MULTIPLE VESSEL ANGIOPLASTY (PTCA) IN PATIENTS WITH CORONARY-ARTERY DISEASE

Roubin, GS, Sutor, C, Lembo, NJ, …, Thomas, Ronald G, et al. | Circulation | vol. 76(4) | 1987 | Conference paper

Topics: Cardiovascular disease Medical research Clinical trials Epidemiology Angioplasty

Is there dependence between sites for continued success or restenosis after successful multisite coronary angioplasty

Thomas, Ronald G, Black, A, Lin, S, Chin, H, Weintraub, WS | Circulation | vol. 76(4) | 1987 | Conference paper

Topics: Cardiovascular disease Biostatistics Medical research Clinical trials Angioplasty

A comparison of single lesion dilatation in single vessel and multivessel disease

Mufson, LGAR, Roubin, GS, Black, A, Thomas, Ronald G | Circulation | vol. 76(4) | 1987 | Conference paper

Topics: Cardiovascular disease Medical research Clinical trials Angioplasty Coronary artery disease

DICHLOROACETATE IMPROVES SURVIVAL-TIME IN LACTIC-ACIDOSIS

Stacpoole, PW, Lorenz, AC, Thomas, Ronald G, HARMAN, EM | CLINICAL RESEARCH | vol. 35(3) | 1987 | Conference paper

Topics: Medical research Clinical trials Drug development Metabolic disease Lactic acidosis

1984

Association of Perinatal Factors with Intracranial Hemorrhage in the Very Low Birthweight, Preterm Neonate

Hutchison, A A, Barrett, J N, Fleischer, A C, Thomas, Ronald G, James, A E, Stahlman, M T | 1984 | Abstract

Topics: Medical research Epidemiology Public health Neonatology Intracranial hemorrhage

1983

Growth Patterns Related to Health and Seasonality Among Economically Disadvantaged Children in Costa Rica

Simpson, S H, Lieberman, L H, Thomas, Ronald G | Proceedings of the Western Hemisphere Nutrition Congress | vol. 7 | 1983 | Conference paper

Topics: Epidemiology Medical research Public health Pediatrics Nutrition

Theses & Technical Reports

2011

Wilfley D

Mockus S. D | Wingard D | vol. Peddeco M. Dietary self-monitoring and its impact on weight loss in overweight children; International Journal of Pediatric Obesity. Aug; 6(3-4) | 2011 | Master’s thesis

Topics: Biostatistics Medical research Longitudinal Missing data Mixed models

1986

A Comparison of the Performance of Confidence Intervals for the Difference of Two Binomial Proportions

Conlon, M, Thomas, Ronald G | Department of Statistics, University of Florida | 1986 | Technical report

Topics: Exact inference Biostatistics Sample size Hypothesis testing Confidence intervals

1983

Parametric Estimation Through the use of the Empirical Characteristic Function

Thomas, Ronald G | University of Washington | 1983 | PhD thesis

Topics: Biostatistics Simulation Exact inference Hypothesis testing Statistical computing

The Application of the Empirical Characteristic Function to the Mixture of Normals Distribution Problem

Thomas, Ronald G, Kronmal, R A | Department of Statistics, University of Florida | 1983 | Technical report

Topics: Biostatistics Simulation Exact inference Hypothesis testing Statistical computing

1982

Application of Fourier Density Estimation Methods to the Mixture of Normal Problems

Thomas, Ronald G | University of Washington | 1982 | Master’s thesis

Topics: Biostatistics Simulation Exact inference Hypothesis testing Statistical computing